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Nutrients 2013, 5(6), 2173-2191;

Protection of Dietary Polyphenols against Oral Cancer

Department of Stomatology, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China
Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
Authors to whom correspondence should be addressed.
Received: 1 March 2013 / Revised: 24 April 2013 / Accepted: 28 May 2013 / Published: 14 June 2013
(This article belongs to the Special Issue Polyphenols and Human Health)
Full-Text   |   PDF [417 KB, uploaded 14 June 2013]


Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels. View Full-Text
Keywords: dietary polyphenols; tea polyphenols; (−)-epigallocatechin-3-gallate; oral cancer; cancer prevention; cancer therapy; cell death; cell growth; cell migration and invasion dietary polyphenols; tea polyphenols; (−)-epigallocatechin-3-gallate; oral cancer; cancer prevention; cancer therapy; cell death; cell growth; cell migration and invasion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ding, Y.; Yao, H.; Yao, Y.; Fai, L.Y.; Zhang, Z. Protection of Dietary Polyphenols against Oral Cancer. Nutrients 2013, 5, 2173-2191.

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