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Advances in Nutritional Research on Regulatory T-Cells

Department of Food Science and Biotechnology, Graduate School of Biotechnology, Kyung Hee University, Yongin, Gyeonggi 446-701, Korea
Department of Food Engineering, Dankook University, Cheonan, Chungnam 330-714, Korea
Author to whom correspondence should be addressed.
Nutrients 2013, 5(11), 4305-4315;
Received: 29 July 2013 / Revised: 17 October 2013 / Accepted: 22 October 2013 / Published: 28 October 2013
PDF [384 KB, uploaded 28 October 2013]


Many clinical and animal studies have shown that certain dietary components exert anti-inflammatory properties that aid in the amelioration of chronic inflammatory diseases. Among the various proposed channels through which dietary components affect immune responses, regulatory T-cells (Tregs) are emerging as key targets for the dietary prevention of chronic inflammatory diseases. In this review, immunoregulation by Tregs is briefly described, followed by a summary of recent advances and possible applications of techniques for the study of Tregs. In addition, this review provides an overview of the current knowledge on Treg regulation by certain dietary components, including vitamins, omega-3 polyunsaturated fatty acids, and polyphenols. The caveats of previous studies are also discussed in order to highlight the distinctions between dietary studies and immunological approaches. Consequently, this review may help to clarify the means by which nutritional components influence Tregs. View Full-Text
Keywords: nutrition; immunology; regulatory T-cells; Tregs; anti-inflammatory nutrition; immunology; regulatory T-cells; Tregs; anti-inflammatory

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kim, W.; Lee, H. Advances in Nutritional Research on Regulatory T-Cells. Nutrients 2013, 5, 4305-4315.

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