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Open AccessArticle

Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair

Black Hills Pediatrics & Neonatology, LLP, 2905 5th Street, Rapid City, SD 57701, USA
USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA
UC Davis Medical Center, University of California, 2516 Stockton Blvd, Sacramento, CA 95817, USA
Author to whom correspondence should be addressed.
Nutrients 2012, 4(9), 1273-1281;
Received: 11 July 2012 / Revised: 7 August 2012 / Accepted: 5 September 2012 / Published: 12 September 2012
(This article belongs to the Special Issue Parenteral Nutrition)
PDF [321 KB, uploaded 12 September 2012]


There is very little data regarding trace mineral nutrition in infants with small intestinal ostomies. Here we evaluated 14 infants with jejunal or ileal ostomies to measure their zinc absorption and retention and biochemical zinc and copper status. Zinc absorption was measured using a dual-tracer stable isotope technique at two different time points when possible. The first study was conducted when the subject was receiving maximal tolerated feeds enterally while the ostomy remained in place. A second study was performed as soon as feasible after full feeds were achieved after intestinal repair. We found biochemical evidence of deficiencies of both zinc and copper in infants with small intestinal ostomies at both time points. Fractional zinc absorption with an ostomy in place was 10.9% ± 5.3%. After reanastamosis, fractional zinc absorption was 9.4% ± 5.7%. Net zinc balance was negative prior to reanastamosis. In conclusion, our data demonstrate that infants with a jejunostomy or ileostomy are at high risk for zinc and copper deficiency before and after intestinal reanastamosis. Additional supplementation, especially of zinc, should be considered during this time period. View Full-Text
Keywords: zinc; copper; ostomy; jejunostomy; ileostomy; nutrient absorption zinc; copper; ostomy; jejunostomy; ileostomy; nutrient absorption
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Balay, K.S.; Hawthorne, K.M.; Hicks, P.D.; Chen, Z.; Griffin, I.J.; Abrams, S.A. Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair. Nutrients 2012, 4, 1273-1281.

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