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Nutrients 2012, 4(7), 782-798;

Maternal Zinc Intakes and Homeostatic Adjustments during Pregnancy and Lactation

Escuela de Nutrición, Universidad de la República, Paysandú 843, Montevideo 11100, Uruguay
Children’s Hospital Oakland Research Institute, 5900 Martin Luther King Jr Way, Oakland, CA 94609, USA
Author to whom correspondence should be addressed.
Received: 2 June 2012 / Revised: 12 July 2012 / Accepted: 13 July 2012 / Published: 24 July 2012
(This article belongs to the Special Issue Zinc in Health and Disease)
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Zinc plays critical roles during embryogenesis, fetal growth, and milk secretion, which increase the zinc need for pregnancy and lactation. Increased needs can be met by increasing the dietary zinc intake, along with making homeostatic adjustments in zinc utilization. Potential homeostatic adjustments include changes in circulating zinc, increased zinc absorption, decreased zinc losses, and changes in whole body zinc kinetics. Although severe zinc deficiency during pregnancy has devastating effects, systematic reviews and meta-analysis of the effect of maternal zinc supplementation on pregnancy outcomes have consistently shown a limited benefit. We hypothesize, therefore, that zinc homeostatic adjustments during pregnancy and lactation improve zinc utilization sufficiently to provide the increased zinc needs in these stages and, therefore, mitigate immediate detrimental effects due to a low zinc intake. The specific questions addressed are the following: How is zinc utilization altered during pregnancy and lactation? Are those homeostatic adjustments influenced by maternal zinc status, dietary zinc, or zinc supplementation? These questions are addressed by critically reviewing results from published human studies on zinc homeostasis during pregnancy and lactation carried out in different populations worldwide. View Full-Text
Keywords: zinc; pregnancy; lactation; diet; homeostasis zinc; pregnancy; lactation; diet; homeostasis

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Donangelo, C.M.; King, J.C. Maternal Zinc Intakes and Homeostatic Adjustments during Pregnancy and Lactation. Nutrients 2012, 4, 782-798.

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