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Folate Production by Probiotic Bacteria

Department of Chemistry, University of Modena and Reggio Emilia, via Campi 183, Modena 41100, Italy
Author to whom correspondence should be addressed.
Nutrients 2011, 3(1), 118-134;
Received: 3 December 2010 / Revised: 24 December 2010 / Accepted: 17 January 2011 / Published: 18 January 2011
(This article belongs to the Special Issue Folate Metabolism and Nutrition)
Probiotic bacteria, mostly belonging to the genera Lactobacillus and Bifidobacterium, confer a number of health benefits to the host, including vitamin production. With the aim to produce folate-enriched fermented products and/or develop probiotic supplements that accomplish folate biosynthesis in vivo within the colon, bifidobacteria and lactobacilli have been extensively studied for their capability to produce this vitamin. On the basis of physiological studies and genome analysis, wild-type lactobacilli cannot synthesize folate, generally require it for growth, and provide a negative contribution to folate levels in fermented dairy products. Lactobacillus plantarum constitutes an exception among lactobacilli, since it is capable of folate production in presence of para-aminobenzoic acid (pABA) and deserves to be used in animal trials to validate its ability to produce the vitamin in vivo. On the other hand, several folate-producing strains have been selected within the genus Bifidobacterium, with a great variability in the extent of vitamin released in the medium. Most of them belong to the species B. adolescentis and B. pseudocatenulatum, but few folate producing strains are found in the other species as well. Rats fed a probiotic formulation of folate-producing bifidobacteria exhibited increased plasma folate level, confirming that the vitamin is produced in vivo and absorbed. In a human trial, the same supplement raised folate concentration in feces. The use of folate-producing probiotic strains can be regarded as a new perspective in the specific use of probiotics. They could more efficiently confer protection against inflammation and cancer, both exerting the beneficial effects of probiotics and preventing the folate deficiency that is associated with premalignant changes in the colonic epithelia. View Full-Text
Keywords: folate; probiotic; Lactobacillus; Bifidobacterium; microbiota; gut folate; probiotic; Lactobacillus; Bifidobacterium; microbiota; gut
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MDPI and ACS Style

Rossi, M.; Amaretti, A.; Raimondi, S. Folate Production by Probiotic Bacteria. Nutrients 2011, 3, 118-134.

AMA Style

Rossi M, Amaretti A, Raimondi S. Folate Production by Probiotic Bacteria. Nutrients. 2011; 3(1):118-134.

Chicago/Turabian Style

Rossi, Maddalena, Alberto Amaretti, and Stefano Raimondi. 2011. "Folate Production by Probiotic Bacteria" Nutrients 3, no. 1: 118-134.

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