Fractional Absorption of Active Absorbable Algal Calcium (AAACa) and Calcium Carbonate Measured by a Dual Stable-Isotope Method
Abstract
:1. Introduction
2. Experimental Section
2.1. Subjects
No. | Age | Years after menopause | Height (cm) | Weight (kg) | Systolic blood pressure (mmHg) | Diastolic blood pressure (mmHg) |
---|---|---|---|---|---|---|
1 | 68 | 19 | 154 | 54 | 138 | 80 |
2 | 72 | 23 | 147 | 50 | 142 | 62 |
3 | 65 | 15 | 157 | 63 | 148 | 70 |
4 | 65 | 13 | 148 | 43 | 125 | 70 |
(5) * | (59) | (9) | (153) | (60) | (133) | (88) |
6 | 59 | 8 | 152 | 58 | 152 | 85 |
7 | 65 | 13 | 151 | 56 | 150 | 85 |
8 | 77 | 28 | 150 | 48 | 142 | 80 |
9 | 64 | 15 | 145 | 50 | 140 | 90 |
10 | 71 | 19 | 148 | 48 | 122 | 70 |
Mean | 67 | 17 | 150 | 52 | 139 | 76 |
SD | 5.3 | 6.0 | 3.7 | 6.1 | 10.4 | 9.3 |
2.2. Background Data of the Test Subjects
No. | Serum Ca | Serum P | Serum albumin | Serum creatinine | BUN | 25(OH) vitamin D | Intact PTH | BAP | Urine NTx/Cr | Urine Ca/Cr |
---|---|---|---|---|---|---|---|---|---|---|
mg/dL | mg/dL | g/dL | mg/dL | mg/dL | ng/dL | pg/dL | U/L | nMBCE/mMCr | mg/mg | |
1 | 9.7 | 3.9 | 4.4 | 0.83 | 11.0 | 16.8 | 48 | 15.2 | 32.2 | 0.03 |
2 | 9.5 | 4.5 | 4.0 | 0.80 | 21.9 | 16.9 | 31 | 15.1 | 16.0 | 0.06 |
3 | 9.7 | 3.1 | 4.6 | 0.71 | 12.1 | 11.6 | 40 | 35.8 | 31.1 | 0.45 |
4 | 10.3 | 3.5 | 5.1 | 0.49 | 12.5 | 11.7 | 44 | 32.4 | 35.9 | 0.36 |
5 * | (9.5) | (3.4) | (4.5) | (0.74) | (14.2) | (21.8) | (61) | (21.6) | (29.0) | (0.08) |
6 | 9.8 | 3.5 | 4.7 | 0.74 | 17.8 | 15.4 | 44 | 19.1 | 23.0 | 0.12 |
7 | 9.3 | 4.4 | 4.4 | 0.60 | 17.8 | 24.7 | 42 | 17.0 | 42.2 | 0.22 |
8 | 9.9 | 2.9 | 4.6 | 0.59 | 13.5 | 7.6 | 50 | 34.9 | 34.5 | 0.17 |
9 | 9.8 | 3.7 | 4.4 | 0.74 | 13.7 | 12.7 | 34 | 27.5 | 16.3 | 0.20 |
10 | 9.5 | 3.3 | 4.2 | 0.54 | 13.6 | 10.8 | 34 | 45.9 | 21.9 | 0.30 |
Mean | 9.7 | 3.6 | 4.5 | 0.67 | 14.9 | 14.2 | 41 | 27.0 | 28.1 | 0.21 |
SD | 0.29 | 0.55 | 0.31 | 0.119 | 3.53 | 4.95 | 6.59 | 11.02 | 9.20 | 0.138 |
2.3. Materials
Isotope | Oral | IV | |||||
---|---|---|---|---|---|---|---|
CaX | CaY | Total | |||||
Supplied | Added | Total | Supplied | Added | Total | ||
42Ca | 0.01 | 1.79 | 1.80 | 0.00 | 1.79 | 1.79 | 3.192 |
43Ca | 0.01 | 0.39 | 0.40 | 0.00 | 0.39 | 0.39 | 0.0037 |
44Ca | 25.38 | 5.52 | 30.90 | 25.38 | 5.53 | 30.91 | 0.0334 |
2.4. Test Procedure
2.4.1. Measurement of the Stable Isotope
2.5. Statistical Analysis
3. Results and Discussion
Subject | FA CaCO3 | FA AAACa |
---|---|---|
1 | 7.5 | 21.1 |
2 | 20.0 | 29.7 |
3 | 21.9 | 34.7 |
4 | 19.6 | 20.4 |
(5) * | (0.0) | (18.8) |
6 | 6.1 | 22.7 |
7 | 14.3 | 24.9 |
8 | 11.7 | 11.9 |
9 | 8.7 | 22.1 |
10 | 22.2 | 20.4 |
Mean | 14.7 | 23.1 |
SD | 6.4 | 6.4 |
FA CaCO3 | FA AAACa | Age | SCa | SP | Salb | Cre | BUN | 25D | PTH | BAP | UNTx | UCa/Cr | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FA CaCO3 | 1.0000 | 0.1423 | 0.4238 | −0.3882 | −0.1925 | −0.3405 | −0.4854 | −0.0335 | −0.3167 | −0.5630 | −0.4833 | −0.1333 | 0.6333 |
FA AAACa | 1.0000 | −0.3490 | −0.5297 | 0.4328 | −0.2137 | 0.5042 | 0.3445 | 0.5690 | −0.5232 | −0.3766 | −0.2762 | 0.0418 |
4. Conclusions
Acknowledgements
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Uenishi, K.; Fujita, T.; Ishida, H.; Fujii, Y.; Ohue, M.; Kaji, H.; Hirai, M.; Kakumoto, M.; Abrams, S.A. Fractional Absorption of Active Absorbable Algal Calcium (AAACa) and Calcium Carbonate Measured by a Dual Stable-Isotope Method. Nutrients 2010, 2, 752-761. https://doi.org/10.3390/nu2070752
Uenishi K, Fujita T, Ishida H, Fujii Y, Ohue M, Kaji H, Hirai M, Kakumoto M, Abrams SA. Fractional Absorption of Active Absorbable Algal Calcium (AAACa) and Calcium Carbonate Measured by a Dual Stable-Isotope Method. Nutrients. 2010; 2(7):752-761. https://doi.org/10.3390/nu2070752
Chicago/Turabian StyleUenishi, Kazuhiro, Takuo Fujita, Hiromi Ishida, Yoshio Fujii, Mutsumi Ohue, Hiroshi Kaji, Midori Hirai, Mikio Kakumoto, and Steven A. Abrams. 2010. "Fractional Absorption of Active Absorbable Algal Calcium (AAACa) and Calcium Carbonate Measured by a Dual Stable-Isotope Method" Nutrients 2, no. 7: 752-761. https://doi.org/10.3390/nu2070752