Next Article in Journal
AI-Powered Analysis of Weight Loss Reports from Reddit: Unlocking Social Media’s Potential in Dietary Assessment
Next Article in Special Issue
Prospective Associations of Dietary Antioxidant Vitamin Intake and 8-Year Risk of Elevated Serum C-Reactive Protein Levels
Previous Article in Journal
Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women
Previous Article in Special Issue
Association Between Circulating Vitamin K Levels, Gut Microbiome, and Type 1 Diabetes: A Mendelian Randomization Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 17
Issue 5
10.3390/nu17050816
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Evaluation of Vitamin D Supplementation in Critically Ill Patients—A Narrative Review of Randomized Controlled Trials Published in the Last 5 Years

by
Shan Wang
1,
Ruodi Ren
2,
Kunkun Wang
3,
Christopher Leo
4,
Mengyan Li
5,
Allison Chow
6,
Andrew K. Yang
7 and
Yun Lu
2,8,*
1
NYU Langone Hospital—Long Island, Mineola, NY 11501, USA
2
College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
3
Fairbanks Memorial Hospital, 340 Cowles Street, Fairbanks, AK 99701, USA
4
Duke Raleigh Hospital, a Campus of Duke University Hospital, School of Medicine, Duke University, Durham, NC 27708, USA
5
Brigham and Women’s Hospital, Boston, MA 02115, USA
6
College of Arts and Science, New York University, New York, NY 10012, USA
7
Dartmouth College, Hanover, NH 03755, USA
8
Department of Pharmacy, Hennepin Healthcare System, Minneapolis, MN 55415, USA
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(5), 816; https://doi.org/10.3390/nu17050816
Submission received: 20 January 2025 / Revised: 18 February 2025 / Accepted: 19 February 2025 / Published: 27 February 2025
(This article belongs to the Special Issue Vitamins and Human Health: 2nd Edition)
Browse Figure
Versions Notes

Abstract

The prevalence of vitamin D deficiency among intensive care unit (ICU) patients is potentially associated with an increased risk of mechanical ventilation, sepsis, prolonged hospital stays, and mortality. Although ICU patient care has significantly improved in recent years, the role of vitamin D supplementation remains under investigation. A literature review was conducted using PubMed, Web of Science, Embase, and Cochrane databases, focusing on randomized controlled trials published in the past five years on vitamin D supplementation in adult ICU patients. Patients’ baseline vitamin D levels, administration routes, doses, biomarker changes, mechanical ventilation duration, length of hospital stay, and mortality were analyzed. Although vitamin D supplementation appears safe and may reduce ICU stay duration and mechanical ventilation time and improve SOFA scores, its impact on overall mortality remains uncertain. Routine supplementation for all ICU patients is not currently recommended; clinical decisions should consider individual baseline vitamin D levels, patient characteristics, severity of illness, doses, and administration methods.
Keywords: clinical outcomes; vitamin D deficiency; vitamin D replacement; critically ill patients; vitamin D doses clinical outcomes; vitamin D deficiency; vitamin D replacement; critically ill patients; vitamin D doses

Share and Cite

MDPI and ACS Style

Wang, S.; Ren, R.; Wang, K.; Leo, C.; Li, M.; Chow, A.; Yang, A.K.; Lu, Y. Evaluation of Vitamin D Supplementation in Critically Ill Patients—A Narrative Review of Randomized Controlled Trials Published in the Last 5 Years. Nutrients 2025, 17, 816. https://doi.org/10.3390/nu17050816

AMA Style

Wang S, Ren R, Wang K, Leo C, Li M, Chow A, Yang AK, Lu Y. Evaluation of Vitamin D Supplementation in Critically Ill Patients—A Narrative Review of Randomized Controlled Trials Published in the Last 5 Years. Nutrients. 2025; 17(5):816. https://doi.org/10.3390/nu17050816

Chicago/Turabian Style

Wang, Shan, Ruodi Ren, Kunkun Wang, Christopher Leo, Mengyan Li, Allison Chow, Andrew K. Yang, and Yun Lu. 2025. "Evaluation of Vitamin D Supplementation in Critically Ill Patients—A Narrative Review of Randomized Controlled Trials Published in the Last 5 Years" Nutrients 17, no. 5: 816. https://doi.org/10.3390/nu17050816

APA Style

Wang, S., Ren, R., Wang, K., Leo, C., Li, M., Chow, A., Yang, A. K., & Lu, Y. (2025). Evaluation of Vitamin D Supplementation in Critically Ill Patients—A Narrative Review of Randomized Controlled Trials Published in the Last 5 Years. Nutrients, 17(5), 816. https://doi.org/10.3390/nu17050816

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop