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Nutrients
Volume 17
Issue 21
10.3390/nu17213451
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Review

The Multi-Dimensional Action Map of Resveratrol Against Alzheimer’s Disease: Mechanism Integration and Treatment Strategy Optimization

by
Yichen Liu
,
Yadan Dong
,
Zhen Cao
,
Yixuan Ji
,
Xiaoxin Cheng
* and
Xu Zheng
*
College of Basic Medical Science, Dalian Medical University, Dalian 116044, China
*
Authors to whom correspondence should be addressed.
Nutrients 2025, 17(21), 3451; https://doi.org/10.3390/nu17213451 (registering DOI)
Submission received: 9 September 2025 / Revised: 24 October 2025 / Accepted: 30 October 2025 / Published: 31 October 2025
(This article belongs to the Special Issue Antioxidants in Diet: Metabolic Impacts and Mechanisms of Action)
Versions Notes

Abstract

Alzheimer’s disease (AD) represents a prevalent neurodegenerative disorder marked by a gradual decline in cognitive and behavioral functions. Despite advancements in elucidating several potential mechanisms underlying the pathogenesis of AD, there remains a limitation in effective supplements or medications for its intervention. Resveratrol, a natural antioxidant, has emerged as a significant player in the treatment of AD. This article reviews the role of resveratrol in four key aspects: amyloid plaque deposition and neurofibrillary tangles, inflammatory response and oxidative stress, energy metabolism and mitochondrial homeostasis, and neuroprotection and regeneration. Furthermore, we also explore treatment strategies to enhance the therapeutic effect of resveratrol.
Keywords: Alzheimer’s disease; resveratrol; anti-inflammatory; neuroprotection; mitochondrial homeostasis Alzheimer’s disease; resveratrol; anti-inflammatory; neuroprotection; mitochondrial homeostasis

Share and Cite

MDPI and ACS Style

Liu, Y.; Dong, Y.; Cao, Z.; Ji, Y.; Cheng, X.; Zheng, X. The Multi-Dimensional Action Map of Resveratrol Against Alzheimer’s Disease: Mechanism Integration and Treatment Strategy Optimization. Nutrients 2025, 17, 3451. https://doi.org/10.3390/nu17213451

AMA Style

Liu Y, Dong Y, Cao Z, Ji Y, Cheng X, Zheng X. The Multi-Dimensional Action Map of Resveratrol Against Alzheimer’s Disease: Mechanism Integration and Treatment Strategy Optimization. Nutrients. 2025; 17(21):3451. https://doi.org/10.3390/nu17213451

Chicago/Turabian Style

Liu, Yichen, Yadan Dong, Zhen Cao, Yixuan Ji, Xiaoxin Cheng, and Xu Zheng. 2025. "The Multi-Dimensional Action Map of Resveratrol Against Alzheimer’s Disease: Mechanism Integration and Treatment Strategy Optimization" Nutrients 17, no. 21: 3451. https://doi.org/10.3390/nu17213451

APA Style

Liu, Y., Dong, Y., Cao, Z., Ji, Y., Cheng, X., & Zheng, X. (2025). The Multi-Dimensional Action Map of Resveratrol Against Alzheimer’s Disease: Mechanism Integration and Treatment Strategy Optimization. Nutrients, 17(21), 3451. https://doi.org/10.3390/nu17213451

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