Self-Reported Non-Celiac Wheat Sensitivity and Other Food Sensitivities in Patients with Primary Sjögren’s Syndrome
Abstract
1. Introduction
2. Materials and Methods
2.1. Inclusion and Exclusion
- Age ≥18 and ≤75 years;
- Diagnosis of pSS according to the 2016 ACR/EULAR criteria [40];
- Written consent to participate in the study.
- Age ≥18 and ≤75 years;
- Absence of the minimal criteria for pSS [40], or no diagnosis of other autoimmune disorders (excluding Hashimoto’s thyroiditis), in accordance with the current international criteria;
- Written consent to participate in the study.
- Diagnosis of CeD, according to current diagnostic criteria [43];
- Self-exclusion of wheat from the diet and refusal to reintroduce it for diagnostic purposes before entering the study (whenever required to exclude CeD);
- Drug and/or alcohol abuse (>30 g/day for men and >20 g/day for women);
- Treatment with systemic steroids and/or non-steroidal anti-inflammatory and/or immunosuppressive drugs in the 2 weeks before duodenal biopsy (whenever required to exclude CeD);
- Pregnancy or breastfeeding;
- Diagnosis of chronic inflammatory bowel disease or other organic pathologies affecting the digestive system (e.g., WA, microscopic colitis, diverticulitis, segmental colitis associated with diverticulosis, etc.), neurological diseases, major psychiatric disorders, infectious diseases, immunological deficiencies, and impairment limiting physical activity;
- Incomplete medical records;
- Lack of a clinical follow-up of at least 12 months after diagnosis with >2 outpatient visits during the follow-up period.
2.2. Outcomes
- Primary outcome: prevalence of self-reported NCWS and/or other food sensitivities in pSS patients
- Secondary outcome: evaluation of the demographic, clinical and immunological characteristics of pSS patients with or without self-reported NCWS
- -
- Anti-nuclear antibody (ANA) titers and patterns;
- -
- Anti-SSA/Ro antibodies (Sjögren’s-syndrome-related antigen A);
- -
- Anti-SSB/La antibodies (Sjögren’s-syndrome-related antigen B);
- -
- Rheumatoid factor (RF);
- -
- C3 and C4 complement component;
- -
- γ-globulinemia;
- -
- Monoclonal component of the γ-globulin fraction.
2.3. Statistical Analysis
3. Results
3.1. Primary Outcome: Prevalence of Self-Reported NCWS and/or Sensitivities/Intolerance to Other Foods
3.2. Secondary Outcome: Evaluation of the Demographic, Clinical and Immunological Features of pSS Patients With or Without Self-Reported NCWS
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ACR | American College of Rheumatology |
ANA | Anti-nuclear antibodies |
anti-SSA/Ro | anti-Sjögren’s-syndrome-related antigen A |
anti-SSB/La | anti-Sjögren’s-syndrome-related antigen B |
ATIs | Amylase-trypsin inhibitors |
CeD | Celiac disease |
DBPCWC | Double-blind placebo-controlled wheat challenge |
DM | Type 2 diabetes mellitus |
ESSDAI | EULAR Sjögren’s syndrome disease activity index |
ESSPRI | EULAR Sjögren’s syndrome patient-reported index |
EULAR | European League Against Rheumatism (now European Alliance of Associations for Rheumatology) |
GFD | Gluten-free diet |
IFN-γ | Interferon-γ |
IL | Interleukin |
IP | Intestinal permeability |
MFS | Multiple food sensitivity |
NCWS | Non-celiac wheat sensitivity |
NO | Nitric oxide |
pSS | Primary Sjögren’s syndrome |
RF | Rheumatoid factor |
SRMI | Self-reported milk intolerance |
TLR-4 | Toll-like receptor-4 |
TNF-α | Tumor necrosis factor-α |
WA | Wheat allergy |
WFD | Wheat-free diet |
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pSS (N = 82) | Controls (N = 161) | p | |
---|---|---|---|
Age (years) (mean ± SD) | 62.5 ± 11.1 | 63.8 ± 12.7 | NS |
Gender (n, %) | |||
1. Male | 4 (4.9) | 20 (12.4) | NS |
2. Female | 78 (91.0) | 141 (87.6) | |
Ethnicity (n, %) | |||
1. Caucasian | 82 (100.0) | 146 (90.7) | 0.03 |
2. African | 0 (0.0) | 15 (9.3) | NS |
3. Asian | 0 (0.0) | 0 (0.0) | NS |
4. Middle Eastern | 0 (0.0) | 0 (0.0) | NS |
Marital status (n, %) | |||
1. Single | 11 (13.4) | 12 (7.5) | NS |
2. Married | 58 (70.7) | 125 (77.6) | NS |
3. Divorced | 3 (3.7) | 9 (5.6) | NS |
4. Widowed | 10 (12.2) | 15 (9.3) | NS |
Qualifications (n, %) | |||
1. None | 3 (3.7) | 6 (3.7) | NS |
2. Elementary school diploma | 8 (9.8) | 51 (31.7) | 0.0003 |
3. Middle school diploma | 32 (39.0) | 86 (53.4) | 0.047 |
4. High school diploma | 29 (35.4) | 12 (7.5) | <0.0001 |
5. University degree | 10 (12.2) | 6 (3.7) | 0.025 |
Employment status (n, %) | |||
1. Employee | 16 (19.5) | 36 (22.4) | NS |
2. Freelance/Professional | 5 (6.1) | 6 (3.7) | NS |
3. Laborer/unskilled worker, craftsperson | 2 (2.4) | 0 (0.0) | NS |
4. Unemployed | 43 (52.5) | 110 (68.3) | 0.022 |
5. Looking for work | 2 (2.4) | 3 (1.9) | NS |
6. Unable to work | 0 (0.0) | 0 (0.0) | NS |
7. Other | 14 (17.1) | 6 (3.7) | 0.0009 |
pSS (N = 82) | Controls (N = 161) | p | |
---|---|---|---|
Episodes of abdominal pain or heaviness or discomfort in the last 12 months (n, %) | 56 (68.3) | 69 (42.9) | 0.0003 |
Frequency of episodes of abdominal pain or heaviness or discomfort (n, %) | N = 56 | N = 69 | |
1. One day a month | 9 (16.1) | 9 (13) | NS |
2. Two days a month | 5 (8.9) | 12 (17.4) | NS |
3. Three days a month | 8 (14.3) | 12 (17.4) | NS |
4. Four days a month | 7 (12.5) | 15 (21.7) | NS |
5. 5–10 days per month | 9 (16.1) | 15 (21.7) | NS |
6. More than 10 days a month | 18 (32.1) | 6 (8.7) | 0.0021 |
Reduction in abdominal pain or heaviness or discomfort after having a bowel movement (n, %) | N = 56 | N = 69 | |
41 (73.2) | 48 (69.6) | NS | |
Abdominal swelling in the last 12 months (n, %) | 50 (60.9) | 39 (24.2) | <0.0001 |
Reduction in abdominal swelling after having a bowel movement (n, %) | N = 50 | N = 39 | |
37 (74.0) | 28 (71.8) | NS | |
Self-reported association between intestinal disorders and a change in usual bowel moments (n, %) | N = 56 | N = 69 | |
42 (75.0) | 39 (56.5) | 0.049 | |
Type of modification in usual bowel movements (n, %) | N = 42 | N = 39 | |
1. Diarrhea | 10 (23.8) | 5 (12.8) | NS |
2. Constipation | 13 (31.0) | 17 (43.6) | NS |
3. Mixed bowel movements | 11 (26.2) | 8 (20.5) | NS |
4. Other | 8 (19.0) | 9 (23.1) | NS |
Association between intestinal disorders and episodes of psychophysical stress (n, %) | N = 56 | N = 69 | |
42 (75.0) | 39 (56.5) | 0.049 | |
Associated comorbidities (n, %) | |||
1. Anxiety | 45 (54.9) | 51 (31.7) | 0.0008 |
2. Depression | 19 (23.2) | 24 (14.9) | NS |
3. Bipolar disorder | 2 (2.4) | 0 (0.0) | NS |
4. Schizophrenia | 0 (0.0) | 0 (0.0) | NS |
5. Thyroid diseases | 27 (32.9) | 15 (9.3) | <0.0001 |
6. Diabetes mellitus | 5 (6.1) | 161 (100.0) | <0.0001 |
7. Pernicious anemia (vitamin B12 deficiency) | 2 (2.4) | 3 (1.9) | NS |
8. Chronic fatigue | 27 (32.9) | 48 (29.8) | NS |
9. Fibromyalgia | 24 (29.3) | 0 (0.0) | <0.0001 |
10. Chronic intestinal inflammatory diseases | 0 (0.0) | 0 (0.0) | NS |
11. Chronic headache | 16 (19.5) | 9 (5.6) | 0.001 |
12. Irritable bowel syndrome | 33 (40.2) | 9 (5.6) | <0.0001 |
13. Celiac disease | 0 (0.0) | 0 (0.0) | NS |
14. Gastroesophageal reflux | 42 (51.2) | 66 (41.0) | NS |
15. Other autoimmune diseases | 19 (23.1) | 0 (0.0) | <0.0001 |
16. Other non-autoimmune diseases | 8 (9.8) | 81 (50.3) | <0.0001 |
pSS (n = 82) | Controls (n = 161) | p | |
---|---|---|---|
Worsening of symptoms related to pSS after eating wheat-containing foods (n, %) | 18 (21.9) | NA | NA |
Clinical manifestations worsened following wheat-containing food intake (n, %) | N = 18 | ||
1. Xerostomia | 8 (44.4) | ||
2. Xerophthalmia | 2 (11.2) | NA | NA |
3. Xerostomia and xerophthalmia | 8 (44.4) | ||
Degree of symptom worsening (n, %) | N = 18 | ||
1. Mild | 6 (33.3) | ||
2. Moderate | 9 (50.0) | NA | NA |
3. Severe | 3 (16.7) | ||
Improvement in one or more of the symptoms related to pSS by eliminating wheat-containing foods from the diet (n, %) | N = 18 | ||
11 (61.1) | NA | NA | |
Clinical manifestations improved following wheat-containing food elimination (n, %) | N = 11 | ||
1. Xerostomia | 3 (27.3) | ||
2. Xerophthalmia | 1 (9.1) | NA | NA |
3. Xerostomia and xerophthalmia | 7 (63.6) | ||
Degree of symptom improvement (n, %) | N = 11 | ||
1. Very slight improvement | 0 (0.0) | ||
2. Slight improvement | 2 (18.2) | ||
3. Satisfactory improvement | 5 (45.4) | NA | NA |
4. Clear improvement which permitted a reduction in therapy | 4 (36.4) | ||
5. Very clear improvement which led to the disappearance of symptoms and permitted therapy to be suspended | 0 (0.0) | ||
Symptoms unrelated to pSS after eating wheat-containing products (n, %) | 39 (47.6) | 30 (18.6) | <0.0001 |
Symptoms referred after eating wheat-containing products (n, %) | N = 39 | N = 30 | |
1. Intestinal bloating | 28 (71.8) | 18 (60.0) | NS |
2. Abdominal pain | 26 (66.7) | 8 (26.7) | 0.002 |
3. Abdominal heaviness | 23 (59.0) | 15 (50.0) | NS |
4. Diarrhea | 14 (35.9) | 3 (10.0) | 0.028 |
5. Constipation | 20 (51.3) | 9 (30.0) | NS |
6. Asthenia | 19 (48.7) | 6 (20.0) | 0.027 |
7. Belching | 10 (25.6) | 6 (20.0) | NS |
8. Flatulence | 20 (51.3) | 1 (3.3) | <0.0001 |
9. Nausea and/or vomiting | 12 (30.8) | 9 (30.0) | NS |
10. Headache | 13 (33.3) | 1 (3.3) | 0.006 |
11. Poor motor coordination | 7 (17.9) | 0 (0.0) | NS |
12. Numbness or prickling sensation on the skin | 9 (23.1) | 1 (3.3) | 0.049 |
13. Anemia | 6 (15.4) | 0 (0.0) | NS |
14. Redness of the skin | 3 (7.7) | 0 (0.0) | NS |
15. Joint pain | 18 (46.2) | 6 (20.0) | 0.045 |
16. Other (indicate) | 0 (0.0) | 0 (0.0) | NS |
Frequency of symptoms after eating wheat-containing foods (n, %) | N = 39 | N = 30 | |
1. Always | 16 (41.0) | 0 (0.0) | <0.0001 |
2. Often (≥3 days/week) | 11 (28.2) | 24 (80.0) | <0.0001 |
3. A few days a week (<3 days/week) | 6 (15.4) | 0 (0.0) | NS |
4. A few times a month (once or more a month) | 5 (12.8) | 6 (20.0) | NS |
5. A few times a year (less than once a month) | 1 (2.6) | 0 (0.0) | NS |
6. Less than once a year | 0 (0.0) | 0 (0.0) | NS |
Timing of symptom onset after wheat-containing food intake (n, %) | N = 39 | N = 30 | |
1. Almost immediately (less than an hour) | 16 (41.0) | 9 (30.0) | NS |
2. 1–6 h | 21 (53.8) | 18 (60.0) | NS |
3. 6–24 h | 0 (0.0) | 3 (10.0) | NS |
4. The next day | 1 (2.6) | 0 (0.0) | NS |
5. A few days | 1 (2.6) | 0 (0.0) | NS |
Duration of symptoms (n, %) | N = 39 | N = 30 | |
1. A few minutes | 4 (10.3) | 12 (40.0) | 0.009 |
2. A few hours | 21 (53.8) | 15 (50.0) | NS |
3. A few days | 11 (28.2) | 3 (10.0) | NS |
4. A few weeks | 2 (5.1) | 0 (0.0) | NS |
5. A few months | 1 (2.6) | 0 (0.0) | NS |
Wheat-containing foods associated with symptom onset (n, %) | N = 39 | N = 30 | |
1. Cereals | 5 (12.8) | 0 (0.0) | NS |
2. Bread | 20 (51.3) | 15 (50.0) | NS |
3. Pasta | 26 (66.7) | 3 (10.0) | <0.0001 |
4. Pizza | 19 (48.7) | 15 (50.0) | NS |
5. Biscuits | 8 (20.5) | 0 (0.0) | 0.008 |
6. Sweets/Candies | 12 (30.8) | 0 (0.0) | 0.001 |
7. Other (specify) | 0 (0.0) | 0 (0.0) | NS |
Period elapsed since the first episodes of wheat intolerance (months) [Median (IQR)] | 120 (48–217) | 5.5 (2–63) | 0.0001 |
Subjects who had consulted a doctor/dietician/health care specialist for wheat-intake-related disorders (n, %) | N = 39 | N = 30 | |
26 (66.7) | 18 (60.0) | NS | |
Professional consulted (multiple answers possible) (n, %) | N = 26 | N = 18 | |
1. Gastroenterologist | 19 (73.1) | 6 (33.3) | 0.021 |
2. General practitioner | 12 (46.2) | 9 (50.0) | NS |
3. Dietitian | 6 (15.4) | 6 (33.3) | NS |
4. Allergologist | 0 (0.0) | 18 (100.0) | <0.0001 |
5. Hematologist | 1 (2.6) | 0 (0.0) | NS |
6. Rheumatologist | 1 (2.6) | 0 (0.0) | NS |
Testing carried out (n, %) | N = 26 | N = 18 | |
1. Celiac disease serology | 16 (61.5) | 3 (16.7) | 0.008 |
2. Prick test for food allergy | 7 (17.9) | 14 (77.8) | 0.003 |
3. Esophagogastroduodenoscopy | 16 (61.5) | 3 (16.7) | 0.008 |
4. Abdomen ultrasound examination | 1 (3.8) | 3 (16.7) | NS |
5. Patch test for nickel allergy | 1 (3.8) | 4 (22.2) | NS |
6. Genetic (HLA) typing | 1 (3.8) | 0 (0.0) | NS |
Possible explanation for referred symptoms given by specialists (n, %) | N = 26 | N = 18 | |
1. Celiac disease | 8 (30.8) | 3 (16.7) | NS |
2. Wheat allergy | 0 (0.0) | 0 (0.0) | NS |
3. Irritable bowel syndrome | 9 (34.6) | 1 (5.6) | NS |
4. NCWS | 3 (11.5) | 0 (0.0) | NS |
5. Gastritis | 1 (3.8) | 0 (0.0) | NS |
6. Diverticulosis | 1 (3.8) | 3 (16.7) | NS |
7. No explanation | 5 (19.2) | 12 (66.7) | 0.004 |
Subjects who had undergone a period of wheat-containing product elimination | N = 39 | N = 30 | |
(n, %) | 20 (51.3) | 0 (0.0) | <0.0001 |
Improvement in one or more of the symptoms by eliminating wheat-containing foods from the diet (n, %) | N = 20 | ||
19 (95.0) | NA | NA | |
Subjects following a wheat-free diet at the time of recruitment (n, %) | N = 20 | ||
15 (75.0) | NA | NA | |
Intake of products containing ancient grains during wheat-free diet (n, %) | N = 20 | ||
10 (50.0) | NA | NA | |
Lack of symptom onset when taking ancient grains (compared to modern grains) (n, %) | N = 10 | ||
8 (80.0) | NA | NA |
pSS (n = 82) | Controls (n = 161) | p | |
---|---|---|---|
Worsening of the symptoms related to pSS after eating non-wheat-containing foods (n, %) | 10 (12.2) | NA | NA |
Clinical manifestations worsened following non-wheat-containing food intake (n, %) | N = 10 | ||
1. Xerostomia | 5 (50.0%) | ||
2. Xerophthalmia | 0 (0.0) | NA | NA |
3. Xerostomia and xerophthalmia | 5 (50.0%) | ||
Degree of symptom worsening (n, %) | N = 10 | ||
1. Mild | 1 (10.0) | ||
2. Moderate | 7 (70.0) | NA | NA |
3. Severe | 2 (20.0) | ||
Improvement in one or more of the symptoms related to pSS by eliminating non-wheat-containing foods from the diet (n, %) | N = 10 | ||
8 (80.0) | NA | NA | |
Clinical manifestations improved following non-wheat-containing food elimination (n, %) | N = 8 | ||
1. Xerostomia | 0 (0.0) | ||
2. Xerophthalmia | 3 (37.5) | NA | NA |
3. Xerostomia and xerophthalmia | 5 (62.5) | ||
Degree of symptom improvement (n, %) | N = 8 | ||
1. Very slight improvement | 0 (0.0) | ||
2. Slight improvement | 3 (37.5) | ||
3. Satisfactory improvement | 1 (12.5) | NA | NA |
4. Clear improvement permitting a reduction in therapy | 4 (50.0) | ||
5. Very clear improvement which led to the disappearance of symptoms and permitted therapy to be suspended | 0 (0.0) | ||
Symptoms unrelated to pSS after eating non-wheat-containing products (n, %) | 35 (42.7) | 21 (13.0) | <0.0001 |
Symptoms referred after eating non-wheat-containing products (n, %) | N = 35 | N = 21 | |
1. Intestinal bloating | 19 (54.3) | 9 (42.9) | NS |
2. Abdominal pain | 18 (51.4) | 6 (28.6) | NS |
3. Abdominal heaviness | 18 (51.4) | 6 (28.6) | NS |
4. Diarrhea | 14 (40.0) | 1 (4.8) | 0.01 |
5. Constipation | 11 (31.4) | 12 (57.1) | NS |
6. Asthenia | 12 (34.2) | 3 (14.3) | NS |
7. Belching | 12 (34.2) | 1 (4.8) | 0.027 |
8. Flatulence | 19 (54.3) | 3 (14.3) | 0.007 |
9. Nausea and/or vomiting | 12 (34.3) | 6 (28.6) | NS |
10. Headache | 9 (25.7) | 3 (14.3) | NS |
11. Poor motor coordination | 5 (14.3) | 0 (0.0) | NS |
12. Numbness or prickling sensation on the skin | 6 (17.1) | 0 (0.0) | NS |
13. Anemia | 3 (8.6) | 0 (0.0) | NS |
14. Redness of the skin | 6 (17.1) | 0 (0.0) | NS |
15. Joint pain | 7 (20.0) | 0 (0.0) | NS |
16. Other (specify) | 0 (0.0) | 0 (0.0) | NS |
Frequency of symptoms after eating non-wheat-containing foods (n, %) | N = 35 | N = 21 | |
1. Always | 14 (40.0) | 15 (71.4) | 0.045 |
2. Often (≥3 days/week) | 14 (40.0) | 6 (28.6) | NS |
3. A few days a week (<3 days/week) | 2 (5.7) | 0 (0.0) | NS |
4. A few times a month (once or more a month) | 4 (11.4) | 0 (0.0) | NS |
5. A few times a year (less than once a month) | 1 (2.9) | 0 (0.0) | NS |
6. Less than once a year | 0 (0.0) | 0 (0.0) | NS |
Timing of symptom onset after non-wheat-containing food intake (n, %) | N = 35 | N = 21 | |
1. Almost immediately (less than an hour) | 14 (40.0) | 6 (28.6) | NS |
2. 1–6 h | 18 (51.4) | 12 (57.1) | NS |
3. 6–24 h | 3 (8.6) | 0 (0,0) | NS |
4. The next day | 0 (0.0) | 3 (14.3) | NS |
5. A few days | 0 (0.0) | 0 (0.0) | NS |
Duration of symptoms (n, %) | N = 35 | N = 21 | |
1. A few minutes | 7 (20.0) | 6 (28.6) | NS |
2. A few hours | 22 (62.9) | 15 (71.4) | NS |
3. A few days | 6 (17.1) | 0 (0.0) | NS |
4. A few weeks | 0 (0.0) | 0 (0.0) | NS |
5. A few months | 0 (0.0) | 0 (0.0) | NS |
Period elapsed since the first episodes of wheat intolerance (months) [Median (IQR)] | 129 (60–240) | 120 (36–240) | NS |
Subjects who had consulted a doctor/dietician/health care specialist for wheat-intake-related disorders (n, %) | N = 35 | N = 21 | |
28 (80.0) | 3 (14.3) | <0.0001 | |
Professional consulted (multiple answers possible) (n, %) | N = 28 | N = 3 | |
1. Gastroenterologist | 12 (42.9) | 2 (66.7) | NS |
2. General practitioner | 17 (60.7) | 2 (66.7) | NS |
3. Dietitian | 3 (10.7) | 0 (0.0) | NS |
4. Allergologist | 2 (7.1) | 0 (0.0) | NS |
5. Hematologist | 1 (3.6) | 0 (0.0) | NS |
6. Rheumatologist | 1 (3.6) | 0 (0.0) | NS |
Testing carried out (n, %) | N = 28 | N = 3 | |
1. Patch test for nickel allergy | 6 (21.4) | 1 (33.3) | NS |
2. Prick test for food allergy | 9 (32.1) | 1 (33.3) | NS |
3. Lactose breath test | 11 (39.3) | 1 (33.3) | NS |
4. Esophagogastroduodenoscopy | 5 (17.9) | 2 (66.7) | NS |
5. Search for food-specific IgE | 1 (3.6) | 0 (0.0) | NS |
Possible explanation for referred symptoms given by specialists (n, %) | N = 28 | N = 3 | |
1. Nickel allergy | 4 (14.3) | 0 (0.0) | NS |
2. Food allergy | 5 (17.9) | 0 (0.0) | NS |
3. Lactose intolerance | 11 (39.3) | 1 (33.3) | NS |
4. Irritable bowel syndrome | 10 (35.7) | 2 (66.7) | NS |
5. No explanation | 6 (21.4) | 1 (33.3) | NS |
OR | CI 95% | p | |
---|---|---|---|
Self-reported NCWS | 3.96 | 2.2–7.13 | <0.0001 |
SRMI | 6.99 | 3.07–15.93 | <0.0001 |
MFS | 4.27 | 2.1–8.68 | 0.0017 |
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Seidita, A.; Mansueto, P.; Soresi, M.; Di Liberto, D.; De Carlo, G.; Bisso, G.; Cosenza, S.; Pistone, M.; Giuliano, A.; Spagnuolo, G.; et al. Self-Reported Non-Celiac Wheat Sensitivity and Other Food Sensitivities in Patients with Primary Sjögren’s Syndrome. Nutrients 2025, 17, 3172. https://doi.org/10.3390/nu17193172
Seidita A, Mansueto P, Soresi M, Di Liberto D, De Carlo G, Bisso G, Cosenza S, Pistone M, Giuliano A, Spagnuolo G, et al. Self-Reported Non-Celiac Wheat Sensitivity and Other Food Sensitivities in Patients with Primary Sjögren’s Syndrome. Nutrients. 2025; 17(19):3172. https://doi.org/10.3390/nu17193172
Chicago/Turabian StyleSeidita, Aurelio, Pasquale Mansueto, Maurizio Soresi, Diana Di Liberto, Gabriele De Carlo, Gianluca Bisso, Salvatore Cosenza, Mirco Pistone, Alessandra Giuliano, Gabriele Spagnuolo, and et al. 2025. "Self-Reported Non-Celiac Wheat Sensitivity and Other Food Sensitivities in Patients with Primary Sjögren’s Syndrome" Nutrients 17, no. 19: 3172. https://doi.org/10.3390/nu17193172
APA StyleSeidita, A., Mansueto, P., Soresi, M., Di Liberto, D., De Carlo, G., Bisso, G., Cosenza, S., Pistone, M., Giuliano, A., Spagnuolo, G., Bertolino, C., Bellanti, C., Citarrella, R., La Barbera, L., Guggino, G., & Carroccio, A. (2025). Self-Reported Non-Celiac Wheat Sensitivity and Other Food Sensitivities in Patients with Primary Sjögren’s Syndrome. Nutrients, 17(19), 3172. https://doi.org/10.3390/nu17193172