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Nutrients
Volume 17
Issue 13
10.3390/nu17132057
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Nutritional and Morphofunctional Assessment in a Cohort of Adults Living with Cystic Fibrosis with or Without Pancreatic Exocrine and/or Endocrine Involvement

by
Ana Piñar-Gutiérrez
1,
José Luis Pereira-Cunill
2,
Andrés Jiménez-Sánchez
2,*,
Silvia García-Rey
1,
María del Carmen Roque-Cuéllar
1,
Antonio J. Martínez-Ortega
2,
Irene González-Navarro
1,
Esther Quintana-Gallego
3,
Ángeles Pizarro
4,
Francisco Javier Castell
5,
Manuel Romero-Gómez
4 and
Pedro Pablo García-Luna
2
1
UGC Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot s/n, 41013 Seville, Spain
2
UGC Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avda. Manuel Siurot s/n, 41013 Seville, Spain
3
UGC Neumología y Cirugía Torácica, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avda. Manuel Siurot s/n, 41013 Seville, Spain
4
UGC Aparato Digestivo, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avda. Manuel Siurot s/n, 41013 Seville, Spain
5
UGC Radiodiagnóstico, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avda. Manuel Siurot s/n, 41013 Seville, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(13), 2057; https://doi.org/10.3390/nu17132057
Submission received: 22 May 2025 / Revised: 17 June 2025 / Accepted: 17 June 2025 / Published: 20 June 2025
(This article belongs to the Section Clinical Nutrition)
Review Reports Versions Notes

Abstract

Objectives: To describe the results of nutritional and morphofunctional assessment in a cohort of adults with cystic fibrosis; to evaluate differences in nutritional status between patients with and without exocrine and/or endocrine pancreatic involvement. Methods: Cross-sectional study: A cohort of adults with cystic fibrosis evaluated in a multidisciplinary unit was analyzed. Pancreatic status was examined, and malnutrition was diagnosed according to GLIM criteria. Morphofunctional assessment consisted of nutritional ultrasound, bioelectrical impedance, handgrip dynamometry, and anthropometry. Qualitative variables are expressed as n (%), quantitative variables as median (IQR). For group comparisons, Fisher’s exact test was used for qualitative variables and the non-parametric median comparison test for quantitative variables. Results: n = 101 participants were recruited, of whom 44 (43.6%) were women. Median age was 33 (25–40.5) years. A total of 64 participants (63.4%) had exocrine pancreatic insufficiency (EPI), 44 (43.6%) had endocrine pancreatic insufficiency, and 28 (27.7%) had cystic fibrosis-related diabetes (CFRD). Median BMI was 23.4 (20.1–24.89) kg/m2. A total of 48 patients (47.5%) were malnourished. Males with EPI had a higher prevalence of undernourishment than those without (56.4% vs. 16.7%, p = 0.005), but not women. CFRD patients displayed no differences in morphofunctional assessment. Conclusions: Almost half the sample was undernourished using GLIM criteria. Males with exocrine pancreatic insufficiency had worse nutritional status. Endocrine pancreatic involvement did not affect nutritional status.
Keywords: cystic fibrosis; morphofunctional assessment; nutritional ultrasound; bioelectrical impedance; handgrip strength; GLIM criteria; cystic fibrosis-related diabetes; exocrine pancreatic insufficiency cystic fibrosis; morphofunctional assessment; nutritional ultrasound; bioelectrical impedance; handgrip strength; GLIM criteria; cystic fibrosis-related diabetes; exocrine pancreatic insufficiency

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MDPI and ACS Style

Piñar-Gutiérrez, A.; Pereira-Cunill, J.L.; Jiménez-Sánchez, A.; García-Rey, S.; Roque-Cuéllar, M.d.C.; Martínez-Ortega, A.J.; González-Navarro, I.; Quintana-Gallego, E.; Pizarro, Á.; Castell, F.J.; et al. Nutritional and Morphofunctional Assessment in a Cohort of Adults Living with Cystic Fibrosis with or Without Pancreatic Exocrine and/or Endocrine Involvement. Nutrients 2025, 17, 2057. https://doi.org/10.3390/nu17132057

AMA Style

Piñar-Gutiérrez A, Pereira-Cunill JL, Jiménez-Sánchez A, García-Rey S, Roque-Cuéllar MdC, Martínez-Ortega AJ, González-Navarro I, Quintana-Gallego E, Pizarro Á, Castell FJ, et al. Nutritional and Morphofunctional Assessment in a Cohort of Adults Living with Cystic Fibrosis with or Without Pancreatic Exocrine and/or Endocrine Involvement. Nutrients. 2025; 17(13):2057. https://doi.org/10.3390/nu17132057

Chicago/Turabian Style

Piñar-Gutiérrez, Ana, José Luis Pereira-Cunill, Andrés Jiménez-Sánchez, Silvia García-Rey, María del Carmen Roque-Cuéllar, Antonio J. Martínez-Ortega, Irene González-Navarro, Esther Quintana-Gallego, Ángeles Pizarro, Francisco Javier Castell, and et al. 2025. "Nutritional and Morphofunctional Assessment in a Cohort of Adults Living with Cystic Fibrosis with or Without Pancreatic Exocrine and/or Endocrine Involvement" Nutrients 17, no. 13: 2057. https://doi.org/10.3390/nu17132057

APA Style

Piñar-Gutiérrez, A., Pereira-Cunill, J. L., Jiménez-Sánchez, A., García-Rey, S., Roque-Cuéllar, M. d. C., Martínez-Ortega, A. J., González-Navarro, I., Quintana-Gallego, E., Pizarro, Á., Castell, F. J., Romero-Gómez, M., & García-Luna, P. P. (2025). Nutritional and Morphofunctional Assessment in a Cohort of Adults Living with Cystic Fibrosis with or Without Pancreatic Exocrine and/or Endocrine Involvement. Nutrients, 17(13), 2057. https://doi.org/10.3390/nu17132057

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