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Nutrients
Volume 17
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10.3390/nu17010004
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Article

Lactobacillus plantarum L11 and Lactobacillus reuteri LR: Ameliorate Obesity via AMPK Pathway

by
Shukun Liang
1,2,
Jintao Sun
1,
Xinshu Gu
1,
Ya Zhao
1,
Xiumin Wang
1,
Hui Tao
1,
Zhenlong Wang
1,
Yougang Zhong
2,
Jinquan Wang
1 and
Bing Han
1,*
1
Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China
2
School of Veterinary Medicine, China Agricultural University, Beijing 100193, China
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(1), 4; https://doi.org/10.3390/nu17010004
Submission received: 8 December 2024 / Revised: 18 December 2024 / Accepted: 19 December 2024 / Published: 24 December 2024
(This article belongs to the Section Nutrition and Obesity)
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Abstract

Objectives: The purpose of this study was to find the potential mechanism of two Lactobacillus (Lactobacillus plantarum L11 and Lactobacillus reuteri LR) on ameliorating obesity, including lipid metabolism and gut microbiota. The two isolates have been studied to have good characterization in vitro, but in vivo studies in modulating lipid metabolism and gut microbiota were not studied. Methods: In this study, mice with HFD supplemented with L11 or LR exhibited slower obesity progression, including reduced weight gain, abdominal fat accumulation, liver damage, inflammation, and adipose lesions. Results: Total cholesterol (TC) and triglycerides (TG) in the serum were significantly reduced (p < 0.01). The inflammatory marker interleukin-6 (IL-6) notably decreased (p < 0.05). Both Lactobacillus strains altered the gut microbiota composition, increasing the relative abundance of Alistipes and Lactobacillus, while L11 also raised Lachnospiraceae abundance. Results of the Western blot analysis showed that L11 and LR influenced the PPAR and AMPK pathways. Conclusions: L11 and LR can effectively reduce obesity by modulating gut microbiota and activating the PPAR–AMPK pathway, leading to decreased liver injury and systemic inflammation in mice fed with an HFD. In the future, the two probiotics may provide a new way for clinically ameliorating obesity on human beings.
Keywords: probiotics; lipid metabolism; gut microbiota; mechanism probiotics; lipid metabolism; gut microbiota; mechanism

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MDPI and ACS Style

Liang, S.; Sun, J.; Gu, X.; Zhao, Y.; Wang, X.; Tao, H.; Wang, Z.; Zhong, Y.; Wang, J.; Han, B. Lactobacillus plantarum L11 and Lactobacillus reuteri LR: Ameliorate Obesity via AMPK Pathway. Nutrients 2025, 17, 4. https://doi.org/10.3390/nu17010004

AMA Style

Liang S, Sun J, Gu X, Zhao Y, Wang X, Tao H, Wang Z, Zhong Y, Wang J, Han B. Lactobacillus plantarum L11 and Lactobacillus reuteri LR: Ameliorate Obesity via AMPK Pathway. Nutrients. 2025; 17(1):4. https://doi.org/10.3390/nu17010004

Chicago/Turabian Style

Liang, Shukun, Jintao Sun, Xinshu Gu, Ya Zhao, Xiumin Wang, Hui Tao, Zhenlong Wang, Yougang Zhong, Jinquan Wang, and Bing Han. 2025. "Lactobacillus plantarum L11 and Lactobacillus reuteri LR: Ameliorate Obesity via AMPK Pathway" Nutrients 17, no. 1: 4. https://doi.org/10.3390/nu17010004

APA Style

Liang, S., Sun, J., Gu, X., Zhao, Y., Wang, X., Tao, H., Wang, Z., Zhong, Y., Wang, J., & Han, B. (2025). Lactobacillus plantarum L11 and Lactobacillus reuteri LR: Ameliorate Obesity via AMPK Pathway. Nutrients, 17(1), 4. https://doi.org/10.3390/nu17010004

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