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Nutrients
Volume 16
Issue 2
10.3390/nu16020256
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Article

Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy

by
Richi Nakatake
1,*,†,
Tetsuya Okuyama
1,†,
Morihiko Ishizaki
1,
Hidesuke Yanagida
1,
Hiroaki Kitade
1,
Katsuhiko Yoshizawa
2,
Mikio Nishizawa
3 and
Mitsugu Sekimoto
1
1
Department of Surgery, Kansai Medical University, Hirakata 573-1010, Osaka, Japan
2
Department of Innovative Food Sciences, School of Food Sciences and Nutrition, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya 663-8558, Hyogo, Japan
3
Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Shiga, Japan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2024, 16(2), 256; https://doi.org/10.3390/nu16020256
Submission received: 6 December 2023 / Revised: 8 January 2024 / Accepted: 11 January 2024 / Published: 14 January 2024
(This article belongs to the Special Issue Vitamins, Nutritional Supplements, Antioxidant Therapy, and Modulators of Inflammation as Therapeutic Interventions)
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Abstract

A standardized extract of cultured Lentinula edodes mycelia (ECLM, AHCC®) has been shown to have beneficial effects on organ metabolism. ECLM has been indicated to have liver protective properties by suppressing inflammatory responses. The pathogenesis of hepatic ischemia-reperfusion injury is thought to involve the induction of inflammatory mediators. However, whether ECLM affects inflammatory mediators caused by warm hepatic ischemia-reperfusion injury and partial hepatectomy (HIRI+PH) has not been clarified. In this study, we evaluated the protective effects of ECLM against liver damage caused by HIRI+PH. Rats were fed a normal diet (HIRI+PH) or a normal diet with 2% ECLM (HIRI+PH and ECLM) for ten days, then the liver and duodenal ligament were clamped and subjected to 15 min of hepatic ischemia. After 70% hepatectomy, the inflow occlusion was released, and liver and blood samples were collected at 3, 6, and 24 h. The effect of ECLM on mortality induced by 30 min of ischemia and hepatectomy was evaluated. The results showed that ECLM attenuated pathological liver damage, including apoptosis, in the rats treated with HIRI+PH, and decreased serum aminotransferase activity; ECLM decreased mRNA levels of the inflammation-related genes inducible nitric oxide synthase and C-X-C motif chemokine ligand 1, and increased mRNA levels of interleukin 10, an anti-inflammatory cytokine; ECLM increased hepatocyte growth factor mRNA levels and Ki-67 labeled nuclei in the liver at 24 h; ECLM significantly reduced HIRI+PH-induced mortality. In conclusion, ECLM may prevent HIRI+PH-induced liver injury in part by suppressing various inflammatory responses and promoting liver regeneration.
Keywords: ECLM; hepatic ischemia-reperfusion injury; partial hepatectomy; inflammatory mediators; liver regeneration ECLM; hepatic ischemia-reperfusion injury; partial hepatectomy; inflammatory mediators; liver regeneration

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MDPI and ACS Style

Nakatake, R.; Okuyama, T.; Ishizaki, M.; Yanagida, H.; Kitade, H.; Yoshizawa, K.; Nishizawa, M.; Sekimoto, M. Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy. Nutrients 2024, 16, 256. https://doi.org/10.3390/nu16020256

AMA Style

Nakatake R, Okuyama T, Ishizaki M, Yanagida H, Kitade H, Yoshizawa K, Nishizawa M, Sekimoto M. Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy. Nutrients. 2024; 16(2):256. https://doi.org/10.3390/nu16020256

Chicago/Turabian Style

Nakatake, Richi, Tetsuya Okuyama, Morihiko Ishizaki, Hidesuke Yanagida, Hiroaki Kitade, Katsuhiko Yoshizawa, Mikio Nishizawa, and Mitsugu Sekimoto. 2024. "Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy" Nutrients 16, no. 2: 256. https://doi.org/10.3390/nu16020256

APA Style

Nakatake, R., Okuyama, T., Ishizaki, M., Yanagida, H., Kitade, H., Yoshizawa, K., Nishizawa, M., & Sekimoto, M. (2024). Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy. Nutrients, 16(2), 256. https://doi.org/10.3390/nu16020256

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