Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials and Animals
2.2. Induction of HIRI+PH in Rats
2.3. Histopathological Analysis
2.4. Weight Change of the Remnant Liver
2.5. Serum Biochemical Analysis
2.6. Reverse Transcriptase Polymerase Chain Reaction
2.7. Statistical Analyses
3. Results
3.1. Pretreatment with ECLM Improved HIRI+PH-Triggered Liver Damage
3.2. ECLM Affects Inflammation- and Apoptosis-Related Gene Expression in the HIRI+PH-Treated Rats
3.3. ECLM Improves Liver Regeneration in the HIRI+PH-Treated Rats
3.4. ECLM Reduces NO Production and iNOS Induction and Elevates Endothelial Nitric Oxide Synthase (eNOS) Induction after HIRI+PH Treatment
3.5. Effects of ECLM on HIRI-Induced Mortality
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Nakatake, R.; Okuyama, T.; Ishizaki, M.; Yanagida, H.; Kitade, H.; Yoshizawa, K.; Nishizawa, M.; Sekimoto, M. Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy. Nutrients 2024, 16, 256. https://doi.org/10.3390/nu16020256
Nakatake R, Okuyama T, Ishizaki M, Yanagida H, Kitade H, Yoshizawa K, Nishizawa M, Sekimoto M. Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy. Nutrients. 2024; 16(2):256. https://doi.org/10.3390/nu16020256
Chicago/Turabian StyleNakatake, Richi, Tetsuya Okuyama, Morihiko Ishizaki, Hidesuke Yanagida, Hiroaki Kitade, Katsuhiko Yoshizawa, Mikio Nishizawa, and Mitsugu Sekimoto. 2024. "Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy" Nutrients 16, no. 2: 256. https://doi.org/10.3390/nu16020256