Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Behavioural Study
2.3. Sacrifice and Brain Tissue Preparation
2.4. Glycaemia
2.5. Glucose Tolerance Test
2.6. Biochemical Plasma Parameters
2.7. Adult Hippocampal Neurogenesis Analysis
2.7.1. 5-Ethynyl-2′-Deoxyuridine (EDU) Injection
2.7.2. EDU Staining
2.8. RNA-Sequencing Analysis
2.8.1. RNA Extraction
2.8.2. RNA-Sequencing Analysis
2.8.3. Data Processing
2.9. Mass Spectrometry
2.9.1. Protein Extraction
2.9.2. Proteomic Preparation
2.9.3. NanoLC-MS/MS Analysis
2.9.4. Data Processing
2.10. Regulon Analysis
2.11. Statistics
3. Results
3.1. Maternal High-Fat Diet Increases Body Weight Gain during Lactation in Offspring, and Induces a Glucose Intolerance in Adult Males
3.2. Maternal High-Fat Diet Leads to Glucose Intolerance in a Sex-Dependent Manner in Offspring
3.3. Maternal High-Fat Diet Impairs Long-Term Spatial Memory in Offspring
3.4. Maternal High-Fat Diet Increases the Number of Proliferating Neural Stem Cells in the Subgranular Zone in Male Offspring
3.5. Maternal High-Fat Diet Impairs Hippocampal Transcriptome in a Sex-Dependent Manner in the Offspring
3.6. Identification of Upstream Regulators Triggering Changes in Gene Expression Induced by Maternal High-Fat Diet
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | WC | WH | Significance | WC | WH | Significance |
---|---|---|---|---|---|---|
Body weight at P21 (g) | 8.6 ± 0.3 | 9.7 ± 0.3 | p = 0.010; ** | 8.2 ± 0.2 | 10.0 ± 0.2 | p = 0.001; *** |
Body weight at the sacrifice—7 months (g) | 34.3 ± 0.7 | 30.4 ± 1.0 | p = 0.006; ** | 24.2 ± 0.7 | 23.4 ± 0.8 | p = 0.765 |
Glycemia fasting (6 h) —7 months (mg/dL) | 166.7 ± 5.5 | 157.2 ± 6.8 | p = 0.284 | 154.8 ± 4.8 | 151.4 ± 6.2 | p = 0.666 |
Insulinemia fasting (6 h) —7 months (µg/L) | 0.7 ± 0.05 | 0.5 ± 0.07 | p = 0.030; * | 0.3 ± 0.04 | 0.3 ± 0.01 | p = 0.128 |
Free fatty acid—7 months (mmol/L) | 0.2 ± 0.03 | 0.1 ± 0.04 | p = 0.862 | 0.2 ± 0.02 | 0.2 ± 0.02 | p = 0.594 |
Triglyceride—7 months (mg/dL) | 53.7 ± 10.5 | 64.0 ± 7.3 | p = 0.431 | 45.9 ± 3.4 | 48.9 ± 2.9 | p = 0.578 |
Cholesterol—7 months (mg/dL) | 61.7 ± 10.1 | 65.3 ± 7.9 | p = 0.788 | 50.1 ± 3.7 | 47.7 ± 3.5 | p = 0.659 |
Temperature (°C) | 37.6 ± 0.1 | 37.5 ± 0.1 | p = 0.540 | 37.4 ± 0.1 | 37.3 ± 0.1 | p = 0.693 |
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Gauvrit, T.; Benderradji, H.; Pelletier, A.; Aboulouard, S.; Faivre, E.; Carvalho, K.; Deleau, A.; Vallez, E.; Launay, A.; Bogdanova, A.; et al. Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring. Nutrients 2023, 15, 4691. https://doi.org/10.3390/nu15214691
Gauvrit T, Benderradji H, Pelletier A, Aboulouard S, Faivre E, Carvalho K, Deleau A, Vallez E, Launay A, Bogdanova A, et al. Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring. Nutrients. 2023; 15(21):4691. https://doi.org/10.3390/nu15214691
Chicago/Turabian StyleGauvrit, Thibaut, Hamza Benderradji, Alexandre Pelletier, Soulaimane Aboulouard, Emilie Faivre, Kévin Carvalho, Aude Deleau, Emmanuelle Vallez, Agathe Launay, Anna Bogdanova, and et al. 2023. "Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring" Nutrients 15, no. 21: 4691. https://doi.org/10.3390/nu15214691