6-Gingerol Ameliorates Adiposity and Inflammation in Adipose Tissue in High Fat Diet-Induced Obese Mice: Association with Regulating of Adipokines
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals and Diets
2.2. Biochemical Analysis
2.3. Histological Analysis
2.4. Western Blot Analysis
2.5. Geme Expression Analysis by Quantitative Real-Time RT-PCR
2.6. Statistical Analysis
3. Results
3.1. 6-Gingerol Reduces Body Weight Gain and Adipose Hypertrophy
3.2. 6-Gingerol Reduces Serum Lipids, Insulin, and Leptin Levels and Improves Insulin Resistance
3.3. 6-Gingerol Modulates the Adipogenesis Involved Gene Expression in WAT
3.4. 6-Gingerol Modulates the Inflammation Involved Gene Expression in WAT
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ND | HFD | HFD + 6G | |
---|---|---|---|
Food intake (g/day) | 3.29 ± 0.17 | 3.19 ± 0.05 | 3.18 ± 0.07 |
Serum TG (mg/dL) | 50.37 ± 2.00 | 51.29 ± 1.97 | 42.16 ± 2.33 * |
Serum FFA (μEg/L) | 590.23 ± 77.36 | 543.69 ± 66.70 | 404.96 ± 60.89 |
Serum TC (mg/dL) | 81.24 ± 22.6 | 128.43 ± 3.63 ### | 134.79 ± 5.06 |
Serum HDL-C (mg/dL) | 42.43 ± 2.14 | 59.30 ± 5.47 ## | 60.55 ± 2.80 |
Serum leptin (ng/mL) | 28.47 ± 3.07 | 81.69 ± 8.35 ### | 46.03 ± 4.70 *** |
Serum adiponectin (mg/dL) | 13.73 ± 0.05 | 11.21 ± 0.03 # | 14.88 ± 0.08 ** |
Serum glucose (mg/dL) | 274.12 ± 17.73 | 386.77 ± 42.16 # | 315.76 ± 17.87 |
Serum insulin (pg/mL) | 364.11 ± 17.38 | 520.86 ± 68.07 # | 348.67 ± 46.90 * |
HOMA-IR | 6.18 ± 0.48 | 12.42 ± 2.32 # | 6.76 ± 0.98 * |
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Hong, K.H.; Um, M.Y.; Ahn, J.; Ha, T.Y. 6-Gingerol Ameliorates Adiposity and Inflammation in Adipose Tissue in High Fat Diet-Induced Obese Mice: Association with Regulating of Adipokines. Nutrients 2023, 15, 3457. https://doi.org/10.3390/nu15153457
Hong KH, Um MY, Ahn J, Ha TY. 6-Gingerol Ameliorates Adiposity and Inflammation in Adipose Tissue in High Fat Diet-Induced Obese Mice: Association with Regulating of Adipokines. Nutrients. 2023; 15(15):3457. https://doi.org/10.3390/nu15153457
Chicago/Turabian StyleHong, Kyung Hee, Min Young Um, Jiyun Ahn, and Tae Youl Ha. 2023. "6-Gingerol Ameliorates Adiposity and Inflammation in Adipose Tissue in High Fat Diet-Induced Obese Mice: Association with Regulating of Adipokines" Nutrients 15, no. 15: 3457. https://doi.org/10.3390/nu15153457