Intervention Approaches in Studying the Response to Vitamin D3 Supplementation
Abstract
:1. Introduction
2. Large-Scale Vitamin D Intervention Studies
3. Genome-Wide Analyses
4. Segregation of Participants of Vitamin D Intervention Studies
5. Future View on Vitamin D Intervention Studies
6. Conclusions
Funding
Conflicts of Interest
References
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Study | Number of Participants | Age (Mean) | 25(OH)D3 Level Baseline Final | Duration | Intervention (Vitamin D3 Dose) | |
---|---|---|---|---|---|---|
VITAL (USA) | 25,871 | 67 y | 77 nM | 105 nM | 5.3 y | 50 µg/day |
ViDA (New Zealand) | 5108 | 66 y | 66 nM | 135 nM | 3.3 y | 5000 µg once + 2500 µg/month |
FIND (Finland) | 2495 | 68 y | 75 nM | 110 nM | 5 y | 40 and 80 µg/day |
D2d (USA) | 2423 | 60 y | 70 nM | 135 nM | 2.5 y | 100 µg/day |
DO-HEALTH (Europe) | 2157 | 75 y | 56 nM | 94 nM | 3 y | 50 µg /day |
Study | Number of Participants | Age (Mean) | 25(OH)D3 Level Baseline Final | Duration | Intervention (Vitamin D3 Dose) | |
---|---|---|---|---|---|---|
VitDmet (Finland) | 71 | 67 y | 59 nM | 83 nM | 5 months | 0, 40 or 80 µg/day |
VitDbol (Finland) | 35 | 26 y | 65 nM | 80 nM | 30 days | 2000 µg bolus once |
VitDHiD (Finland) | 40 | 27 y | 73 nM | 98 nM | 1 day | 2000 µg bolus once |
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Gospodarska, E.; Ghosh Dastidar, R.; Carlberg, C. Intervention Approaches in Studying the Response to Vitamin D3 Supplementation. Nutrients 2023, 15, 3382. https://doi.org/10.3390/nu15153382
Gospodarska E, Ghosh Dastidar R, Carlberg C. Intervention Approaches in Studying the Response to Vitamin D3 Supplementation. Nutrients. 2023; 15(15):3382. https://doi.org/10.3390/nu15153382
Chicago/Turabian StyleGospodarska, Emilia, Ranjini Ghosh Dastidar, and Carsten Carlberg. 2023. "Intervention Approaches in Studying the Response to Vitamin D3 Supplementation" Nutrients 15, no. 15: 3382. https://doi.org/10.3390/nu15153382