Next Article in Journal
The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food
Next Article in Special Issue
Dietary Copper and Selenium Intakes and the Risk of Type 2 Diabetes Mellitus: Findings from the China Health and Nutrition Survey
Previous Article in Journal
Acute Effects of Kawakawa (Piper excelsum) Intake on Postprandial Glycemic and Insulinaemic Response in a Healthy Population
Previous Article in Special Issue
Identifying Effects of Urinary Metals on Type 2 Diabetes in U.S. Adults: Cross-Sectional Analysis of National Health and Nutrition Examination Survey 2011–2016
 
 
Article

Iron Bioavailability from Ferrous Ammonium Phosphate, Ferrous Sulfate, and Ferric Pyrophosphate in an Instant Milk Drink—A Stable Isotope Study in Children

1
Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zurich, 8092 Zurich, Switzerland
2
Department of Science and Technology, Food and Nutrition Research Institute, Taguig City 1630, Philippines
3
Clinical Research Unit, Nestlé Research, Société des Produits Nestlé S.A., Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland
4
Nestlé Research and Development China Ltd., Building 5, No 6 Jiu Xian Qiao Road, Chao Yang District, Beijing 100102, China
5
Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Joanna Suliburska
Nutrients 2022, 14(8), 1640; https://doi.org/10.3390/nu14081640
Received: 27 March 2022 / Revised: 9 April 2022 / Accepted: 11 April 2022 / Published: 14 April 2022
(This article belongs to the Special Issue Minerals Metabolism and Human Health)
Ferrous ammonium phosphate (FAP) is an iron salt that has been developed for the fortification of food matrices sensitive to color and flavor changes. The objective of the study was to measure iron absorption from FAP in young children and compare it to a previous evaluation of FAP in young women. A double-blind randomized crossover study with two parallel arms was used to evaluate the iron absorption from FAP added to reconstituted milk powder in comparison to that from ferrous sulfate (FeSO4) and ferric pyrophosphate (FePP). Iron absorption was measured in 39 children aged 3- to 6-years-old using erythrocyte incorporation of stable Fe isotopes (57Fe, 58Fe). The geometric mean iron absorption in iron replete children from FAP, FeSO4 and FePP from milk was 8.3%, 7.6% and 2.1%, respectively. Iron absorption from FAP and FeSO4 fortified milk was not significantly different (p = 0.199); however, it was significantly higher than from FePP fortified milk (p < 0.001). Iron bioavailability from FAP and FePP relative to FeSO4 (relative bioavailability (RBV)) was 110% and 33%, respectively. The RBV of FAP (110%) in iron replete children was higher than previously reported RBV (71%) in mainly iron deficient women. The difference in iron status between the children and women in the respective studies may explain the different RBV values and is discussed. View Full-Text
Keywords: ferrous sulfate; ferrous ammonium phosphate; ferric pyrophosphate; stable isotope; absorption; milk; children ferrous sulfate; ferrous ammonium phosphate; ferric pyrophosphate; stable isotope; absorption; milk; children
MDPI and ACS Style

Hurrell, R.F.; Trinidad, T.P.; Mallillin, A.C.; Sagum, R.S.; Foman, J.T.; Li, Q.; Zeder, C.; Kastenmayer, P.; Rytz, A.; Sabatier, M.; Egli, I. Iron Bioavailability from Ferrous Ammonium Phosphate, Ferrous Sulfate, and Ferric Pyrophosphate in an Instant Milk Drink—A Stable Isotope Study in Children. Nutrients 2022, 14, 1640. https://doi.org/10.3390/nu14081640

AMA Style

Hurrell RF, Trinidad TP, Mallillin AC, Sagum RS, Foman JT, Li Q, Zeder C, Kastenmayer P, Rytz A, Sabatier M, Egli I. Iron Bioavailability from Ferrous Ammonium Phosphate, Ferrous Sulfate, and Ferric Pyrophosphate in an Instant Milk Drink—A Stable Isotope Study in Children. Nutrients. 2022; 14(8):1640. https://doi.org/10.3390/nu14081640

Chicago/Turabian Style

Hurrell, Richard F., Trinidad P. Trinidad, Aida C. Mallillin, Rosario S. Sagum, Jasmin Tajeri Foman, Qiaoji Li, Christophe Zeder, Peter Kastenmayer, Andreas Rytz, Magalie Sabatier, and Ines Egli. 2022. "Iron Bioavailability from Ferrous Ammonium Phosphate, Ferrous Sulfate, and Ferric Pyrophosphate in an Instant Milk Drink—A Stable Isotope Study in Children" Nutrients 14, no. 8: 1640. https://doi.org/10.3390/nu14081640

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop