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Article

Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

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Clinic’n’Cell SAS, Faculty of Medicine and Pharmacy, TSA 50400, 28 Place Henri Dunant, CEDEX 1, 63001 Clermont-Ferrand, France
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Activ’Inside, 33750 Beychac et Caillau, France
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Nutrition-Health & Lipid Biochemistry Department, ITERG, 33610 Canejan, France
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INRAE, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, France
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Department of Life Science and Health, Nutrition and Integrative Neurobiology (NutriNeuro), Bordeaux University, UMR 1286, 33076 Bordeaux, France
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Faculty of Medicine and Health Sciences, Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
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CIC INSERM 1405/Plateforme d’Investigation Clinique CHU Gabriel Montpied, 58 Rue Montalembert, 63000 Clermont-Ferrand, France
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INRAE, UMR 1019, UNH, 63009 Clermont-Ferrand, France
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Human Nutrition Unit, Clermont Auvergne University, BP 10448, 63000 Clermont-Ferrand, France
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Author to whom correspondence should be addressed.
Academic Editor: Dariusz Nowak
Nutrients 2022, 14(7), 1511; https://doi.org/10.3390/nu14071511
Received: 14 March 2022 / Revised: 1 April 2022 / Accepted: 3 April 2022 / Published: 5 April 2022
(This article belongs to the Special Issue Carotene and Carotenoids and Human Health)
Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’InsideTM) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression. View Full-Text
Keywords: clinical trial; depression; serotonin; BDNF; dopamine; SERT; brain; mental health; crocetin; SH-SY5Y clinical trial; depression; serotonin; BDNF; dopamine; SERT; brain; mental health; crocetin; SH-SY5Y
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MDPI and ACS Style

Wauquier, F.; Boutin-Wittrant, L.; Pourtau, L.; Gaudout, D.; Moras, B.; Vignault, A.; Monchaux De Oliveira, C.; Gabaston, J.; Vaysse, C.; Bertrand, K.; Abrous, H.; Capuron, L.; Castanon, N.; Vauzour, D.; Roux, V.; Macian, N.; Pickering, G.; Wittrant, Y. Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders. Nutrients 2022, 14, 1511. https://doi.org/10.3390/nu14071511

AMA Style

Wauquier F, Boutin-Wittrant L, Pourtau L, Gaudout D, Moras B, Vignault A, Monchaux De Oliveira C, Gabaston J, Vaysse C, Bertrand K, Abrous H, Capuron L, Castanon N, Vauzour D, Roux V, Macian N, Pickering G, Wittrant Y. Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders. Nutrients. 2022; 14(7):1511. https://doi.org/10.3390/nu14071511

Chicago/Turabian Style

Wauquier, Fabien, Line Boutin-Wittrant, Line Pourtau, David Gaudout, Benjamin Moras, Adeline Vignault, Camille Monchaux De Oliveira, Julien Gabaston, Carole Vaysse, Karène Bertrand, Hélène Abrous, Lucile Capuron, Nathalie Castanon, David Vauzour, Véronique Roux, Nicolas Macian, Gisèle Pickering, and Yohann Wittrant. 2022. "Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders" Nutrients 14, no. 7: 1511. https://doi.org/10.3390/nu14071511

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