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Article

Incidence and Impact of Refeeding Syndrome in an Internal Medicine and Gastroenterology Ward of an Italian Tertiary Referral Center: A Prospective Cohort Study

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Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica Del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy
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UOC di Nutrizione Clinica, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy
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Scuola di Specializzazione in Medicina Interna, Università Cattolica Del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy
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UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Robert G. Sawyer
Nutrients 2022, 14(7), 1343; https://doi.org/10.3390/nu14071343
Received: 1 March 2022 / Accepted: 21 March 2022 / Published: 23 March 2022
(This article belongs to the Special Issue Hot Topics in Clinical Nutrition)
Background: Refeeding syndrome (RS) is a neglected, potentially fatal syndrome that occurs in malnourished patients undergoing rapid nutritional replenishment after a period of fasting. The American Society for Parenteral and Enteral Nutrition (ASPEN) recently released new criteria for RS risk and diagnosis. Real-life data on its incidence are still limited. Methods: We consecutively enrolled patients admitted to the Internal Medicine and Gastroenterology Unit of our center. The RS risk prevalence and incidence of RS were evaluated according to ASPEN. The length of stay (LOS), mortality, and re-admission rate within 30 days were assessed. Results: Among 203 admitted patients, 98 (48.3%) were at risk of RS; RS occurred in 38 patients (18.7% of the entire cohort). Patients diagnosed with RS had a higher mean LOS (12.5 days ± 7.9) than those who were not diagnosed with RS (7.1 ± 4.2) (p < 0.0001). Nine patients (4.4%) died. Body mass index (OR 0.82; 95% CI 0.69–0.97), RS diagnosis (OR 10.1; 95% CI 2.4–42.6), and medical nutritional support within 48 h (OR 0.12; 95% CI 0.02–0.56) were associated with mortality. Conclusions: RS incidence is high among clinical wards, influencing clinical outcomes. Awareness among clinicians is necessary to identify patients at risk and to support those developing this syndrome. View Full-Text
Keywords: refeeding; malnutrition; ASPEN criteria; mortality; length of hospital stay; readmission refeeding; malnutrition; ASPEN criteria; mortality; length of hospital stay; readmission
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MDPI and ACS Style

Rinninella, E.; D’Angelo, M.; Borriello, R.; Galasso, T.; Cintoni, M.; Raoul, P.; Impagnatiello, M.; Annicchiarico, B.E.; Gasbarrini, A.; Mele, M.C. Incidence and Impact of Refeeding Syndrome in an Internal Medicine and Gastroenterology Ward of an Italian Tertiary Referral Center: A Prospective Cohort Study. Nutrients 2022, 14, 1343. https://doi.org/10.3390/nu14071343

AMA Style

Rinninella E, D’Angelo M, Borriello R, Galasso T, Cintoni M, Raoul P, Impagnatiello M, Annicchiarico BE, Gasbarrini A, Mele MC. Incidence and Impact of Refeeding Syndrome in an Internal Medicine and Gastroenterology Ward of an Italian Tertiary Referral Center: A Prospective Cohort Study. Nutrients. 2022; 14(7):1343. https://doi.org/10.3390/nu14071343

Chicago/Turabian Style

Rinninella, Emanuele, Marco D’Angelo, Raffaele Borriello, Tiziano Galasso, Marco Cintoni, Pauline Raoul, Michele Impagnatiello, Brigida E. Annicchiarico, Antonio Gasbarrini, and Maria C. Mele. 2022. "Incidence and Impact of Refeeding Syndrome in an Internal Medicine and Gastroenterology Ward of an Italian Tertiary Referral Center: A Prospective Cohort Study" Nutrients 14, no. 7: 1343. https://doi.org/10.3390/nu14071343

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