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Systematic Review

Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies

1
GI Department, Metropolitan General Hospital, 15562 Holargos, Greece
2
Hellenic Society of Gastrointestinal Oncology, 354, Iera Odos Street, Haidari, 12461 Athens, Greece
3
Women’s Health Research Unit, Queen Mary University of London, London E1 2AB, UK
4
Hematology Laboratory-Blood Bank, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
5
Special Unit for Biomedical Research and Education, School of Medicine, Aristotle University of Thessaloniki, 60 El. Venizelou Street, Aghia Paraskevi, 15341 Athens, Greece
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Edgard Delvin
Nutrients 2022, 14(3), 619; https://doi.org/10.3390/nu14030619
Received: 21 December 2021 / Revised: 27 January 2022 / Accepted: 27 January 2022 / Published: 30 January 2022
(This article belongs to the Section Phytochemicals and Human Health)
Background: Pancreatic cancer represents the most lethal malignancy among all digestive cancers. Despite the therapeutic advances achieved during recent years, the prognosis of this neoplasm remains disappointing. An enormous amount of experimental (mainly) and clinical research has recently emerged referring to the effectiveness of various plants administered either alone or in combination with chemotherapeutic agents. Apart from Asian countries, the use of these plants and herbals in the treatment of digestive cancer is also increasing in a number of Western countries as well. The aim of this study is to review the available literature regarding the efficacy of plants and herbals in pancreatic cancer. Methods: The authors have reviewed all the experimental and clinical studies published in Medline and Embase, up to June 2021. Results: More than 100 plants and herbals were thoroughly investigated. Favorable effects concerning the inhibition of cancer cell lines in the experimental studies and a favorable clinical outcome after combining various plants with established chemotherapeutic agents were observed. These herbals and plants exerted their activity against pancreatic cancer via a number of mechanisms. The number and severity of side-effects are generally of a mild degree. Conclusion: A quite high number of clinical and experimental studies confirmed the beneficial effect of many plants and herbals in pancreatic cancer. More large, double-blind clinical studies assessing these natural products, either alone or in combination with chemotherapeutic agents should be conducted. View Full-Text
Keywords: alternative treatment; alternative medicine; chinese medicine; herbals; pancreatic cancer; medical plants alternative treatment; alternative medicine; chinese medicine; herbals; pancreatic cancer; medical plants
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MDPI and ACS Style

Triantafillidis, J.K.; Triantafyllidi, E.; Sideris, M.; Pittaras, T.; Papalois, A.E. Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies. Nutrients 2022, 14, 619. https://doi.org/10.3390/nu14030619

AMA Style

Triantafillidis JK, Triantafyllidi E, Sideris M, Pittaras T, Papalois AE. Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies. Nutrients. 2022; 14(3):619. https://doi.org/10.3390/nu14030619

Chicago/Turabian Style

Triantafillidis, John K., Eleni Triantafyllidi, Michail Sideris, Theodoros Pittaras, and Apostolos E. Papalois. 2022. "Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies" Nutrients 14, no. 3: 619. https://doi.org/10.3390/nu14030619

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