Next Article in Journal
Predictive Factors for Oral Immune Modulation in Cow Milk Allergy
Previous Article in Journal
Nutrition in Abrupt Sunlight Reduction Scenarios: Envisioning Feasible Balanced Diets on Resilient Foods
Previous Article in Special Issue
Beneficial Impact of Pork Dry-Cured Ham Consumption on Blood Pressure and Cardiometabolic Markers in Individuals with Cardiovascular Risk
Article

Assessment of the Cholesterol-Lowering Effect of MOMAST®: Biochemical and Cellular Studies

Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Luisa Cigliano and Maret G. Traber
Nutrients 2022, 14(3), 493; https://doi.org/10.3390/nu14030493
Received: 29 December 2021 / Revised: 17 January 2022 / Accepted: 22 January 2022 / Published: 23 January 2022
(This article belongs to the Special Issue Bioactive Peptides)
MOMAST® is a patented phenolic complex derived from the olive oil vegetation water, a by-product of the olive oil supply chain, in which hydroxytyrosol (OH-Tyr) and tyrosol (Tyr) and verbascoside are the main compounds. This study was aimed at investigating its hypocholesterolemic effect by assessing the ability to modulate the low-density lipoprotein (LDL) receptor (LDLR)/sterol regulatory element-binding protein 2 (SREBP-2), and proprotein convertase subtilisin/kexin type 9 (PCSK9) pathways. MOMAST® inhibits the in vitro activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCOAR) with a dose-response trend. After the treatment of HepG2 cells, MOMAST® increases the SREBP-2, LDLR, and HMGCoAR protein levels leading, from a functional point of view to an improved ability of hepatic cells to up-take LDL from the extracellular environment with a final cholesterol-lowering effect. Furthermore, MOMAST® decreased the PCSK9 protein levels and its secretion in the extracellular environment, presumably via the reduction of the hepatic nuclear factor 1-α (HNF1-α). The experiments were performed in parallel, using pravastatin as a reference compound. Results demonstrated that MOMAST® may be exploited as a new ingredient for the development of functional foods and/or nutraceuticals for cardiovascular disease prevention. View Full-Text
Keywords: Cultivar Coratina; by-products; circular economy; cholesterol metabolism; PCSK9 Cultivar Coratina; by-products; circular economy; cholesterol metabolism; PCSK9
Show Figures

Figure 1

MDPI and ACS Style

Bartolomei, M.; Bollati, C.; Li, J.; Arnoldi, A.; Lammi, C. Assessment of the Cholesterol-Lowering Effect of MOMAST®: Biochemical and Cellular Studies. Nutrients 2022, 14, 493. https://doi.org/10.3390/nu14030493

AMA Style

Bartolomei M, Bollati C, Li J, Arnoldi A, Lammi C. Assessment of the Cholesterol-Lowering Effect of MOMAST®: Biochemical and Cellular Studies. Nutrients. 2022; 14(3):493. https://doi.org/10.3390/nu14030493

Chicago/Turabian Style

Bartolomei, Martina, Carlotta Bollati, Jianqiang Li, Anna Arnoldi, and Carmen Lammi. 2022. "Assessment of the Cholesterol-Lowering Effect of MOMAST®: Biochemical and Cellular Studies" Nutrients 14, no. 3: 493. https://doi.org/10.3390/nu14030493

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop