Association between Urinary Advanced Glycation End Products and Subclinical Inflammation in Children and Adolescents: Results from the Italian I.Family Cohort
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experimental Design and Cohort
2.2. Sample Processing and Analytical Procedures
2.3. Inflammatory Biomarkers
2.4. Fluorescence
2.5. Anthropometric and Blood Pressure Measurements
2.6. Medical History and Medication Use
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Below Median (n 361) | Above Median (n 315) | p-Value | |
---|---|---|---|
Urinary AGEs (AU) | 230.4 ± 49.0 | 384.3 ± 123.0 | 0.0001 |
Sex (F/M %) | 45.3/54.7 | 48.6/51.4 | 0.457 |
Age (years) | 11.8 ± 1.6 | 11.8 ± 1.7 | 0.876 |
Height (cm) | 151.3 ± 11.6 | 151.2 ± 11.2 | 0.232 |
Weight (kg) | 50.5 ± 13.8 | 51.1 ± 15.0 | 0.578 |
BMI z-score | 1.2 ± 1.0 | 1.3 ± 1.1 | 0.294 |
SBP (mm Hg) | 108.0 ± 9.0 | 108.4 ± 9.7 | 0.565 |
DBP (mm Hg) | 65.0 ± 6.4 | 65.4 ± 6.4 | 0.343 |
hs-CRP (mg/dL) | 0.24 ± 0.6 | 0.44 ± 1.1 | 0.002 * |
Inflammation Parameters | Urinary AGEs | |
---|---|---|
Correlation Coefficient (Spearman’s Rho) | p-Value (2 Tailed) | |
hs-CRP | 0.258 | 0.0001 |
IP-10 | 0.105 | 0.006 |
IL-15 | 0.131 | 0.001 |
IL-6 | 0.050 | 0.198 |
IL-8 | −0.007 | 0.848 |
TNF-α | 0.004 | 0.912 |
IL-1Ra | 0.138 | 0.001 |
Dependent Variable | Independent Variables | B (SE) | p-Value |
---|---|---|---|
hsCRP(Ln) mg/dl | Sex (m/f) | −0.023 (0.064) | 0.719 |
Age (years) | −0.050 (0.020) | 0.011 | |
BMI z-score | 0.175 (0.030) | 0.0001 | |
Urinary AGEs (category) | 0.189 (0.064) | 0.003 |
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Borriello, M.; Lauria, F.; Sirangelo, I.; Aleksandrova, K.; Hebestreit, A.; Siani, A.; Russo, P. Association between Urinary Advanced Glycation End Products and Subclinical Inflammation in Children and Adolescents: Results from the Italian I.Family Cohort. Nutrients 2022, 14, 4135. https://doi.org/10.3390/nu14194135
Borriello M, Lauria F, Sirangelo I, Aleksandrova K, Hebestreit A, Siani A, Russo P. Association between Urinary Advanced Glycation End Products and Subclinical Inflammation in Children and Adolescents: Results from the Italian I.Family Cohort. Nutrients. 2022; 14(19):4135. https://doi.org/10.3390/nu14194135
Chicago/Turabian StyleBorriello, Margherita, Fabio Lauria, Ivana Sirangelo, Krasimira Aleksandrova, Antje Hebestreit, Alfonso Siani, and Paola Russo. 2022. "Association between Urinary Advanced Glycation End Products and Subclinical Inflammation in Children and Adolescents: Results from the Italian I.Family Cohort" Nutrients 14, no. 19: 4135. https://doi.org/10.3390/nu14194135