Influence of CLOCK Gene Variants on Weight Response after Bariatric Surgery
Abstract
:1. Introduction
2. Materials and Methods
2.1. DNA Extraction and Genotyping of Samples
2.2. Statistical Analyses
3. Results
3.1. Case Control Association Study
3.2. Association Study with Weight Response
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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SNP | Genotype | Controls n (%) | Cases n (%) |
---|---|---|---|
rs3749474 | C/C * | 100 (44.2%) | 142 (37.9%) |
C/T | 101 (44.7%) | 152 (40.5%) | |
T/T | 25 (11.1%) | 81 (21.6%) | |
rs1801260 | A/A * | 115 (50.2%) | 202 (53.9%) |
A/G | 90 (39.3%) | 157 (41.9%) | |
G/G | 24 (10.5%) | 16 (4.3%) | |
rs4580704 | G/G * | 30 (13.1%) | 52 (13.9%) |
G/C | 105 (45.9%) | 169 (45.1%) | |
C/C | 94 (41%) | 154 (41.1%) |
Variable | Value |
---|---|
Age, in years | 44.79 ± 11.99 |
BMI_00, kg/m2 | 44.87 ± 6.59 |
Female gender, n (%) | 259 (69) |
T2D, n (%) | 134 (35.7) |
HTN, n (%) | 182 (49) |
%TWL_nadir, | 38.79 ± 9.84 |
%EWL_nadir, | 91.19 ± 23.69 |
%TWL_6y | 31.67 ± 11.62 |
%EWL_6y | 74.08 ± 26.89 |
%EWL > 50%, n (%) | 311 (82.93) |
%TWL > 20%, n (%) | 317 (84.53) |
%WR_MWL, median (IQR) | 15.76 (7.99–28.69) |
SNP | Genotype | n | %TWL_nadir | %TWL_6y | %WR_MWL |
---|---|---|---|---|---|
rs3749474 | C/C | 142 | 39.48 ± 0.86 | 32.26 ± 0.97 | 20.04 ± 1.55 |
C/T | 152 | 38.11 ± 0.78 | 31.45 ± 0.93 | 19.24 ± 1.31 | |
T/T | 81 | 38.84 ± 1.07 | 31.03 ± 1.35 | 22.35 ± 2.41 | |
rs1801260 | A/A/ | 202 | 38.87 ± 0.67 | 31.22 ± 0.83 | 21.63 ± 1.36 |
A/G | 157 | 38.31 ± 0.82 | 31.73 ± 0.9 | 18.95 ± 1.37 | |
G/G | 16 | 42.43 ± 2.31 | 36.7 ± 2.97 | 14.88 ± 3.61 | |
rs4580704 | G/G | 52 | 39.09 ± 1.22 | 30.65 ± 1.5 | 20.39 ± 1.5 |
G/C | 169 | 39.48 ± 0.8 | 32.56 ± 0.9 | 19.29 ± 1.43 | |
C/C | 154 | 37.93 ± 0.77 | 31.03 ± 0.95 | 22.73 ± 2.32 |
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Torrego-Ellacuría, M.; Barabash, A.; Matía-Martín, P.; Sánchez-Pernaute, A.; Torres, A.J.; Calle-Pascual, A.L.; Rubio-Herrera, M.A. Influence of CLOCK Gene Variants on Weight Response after Bariatric Surgery. Nutrients 2022, 14, 3472. https://doi.org/10.3390/nu14173472
Torrego-Ellacuría M, Barabash A, Matía-Martín P, Sánchez-Pernaute A, Torres AJ, Calle-Pascual AL, Rubio-Herrera MA. Influence of CLOCK Gene Variants on Weight Response after Bariatric Surgery. Nutrients. 2022; 14(17):3472. https://doi.org/10.3390/nu14173472
Chicago/Turabian StyleTorrego-Ellacuría, Macarena, Ana Barabash, Pilar Matía-Martín, Andrés Sánchez-Pernaute, Antonio J. Torres, Alfonso L. Calle-Pascual, and Miguel A. Rubio-Herrera. 2022. "Influence of CLOCK Gene Variants on Weight Response after Bariatric Surgery" Nutrients 14, no. 17: 3472. https://doi.org/10.3390/nu14173472