Diet-Derived Circulating Antioxidants and Risk of Digestive System Tumors: A Mendelian Randomization Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Genetic Instrumental Variables for Antioxidants
2.2. Absolute Circulating Antioxidants
2.3. Circulating Antioxidant Metabolites
2.4. Genetic Variants for Digestive System Tumors
2.5. Statistical Power
2.6. Statistical Analysis
3. Results
3.1. Screening of Genetic Instrumental Variables
3.2. Antioxidants and Colorectal Cancer
3.3. Antioxidants and Gastric Cancer
3.4. Antioxidants and Pancreatic Cancer
3.5. Antioxidants and Liver Cancer
3.6. Antioxidants and Esophageal Cancer
3.7. Meta-Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Yin, L.; Yan, H.; Chen, K.; Ji, Z.; Zhang, X.; Ji, G.; Zhang, B. Diet-Derived Circulating Antioxidants and Risk of Digestive System Tumors: A Mendelian Randomization Study. Nutrients 2022, 14, 3274. https://doi.org/10.3390/nu14163274
Yin L, Yan H, Chen K, Ji Z, Zhang X, Ji G, Zhang B. Diet-Derived Circulating Antioxidants and Risk of Digestive System Tumors: A Mendelian Randomization Study. Nutrients. 2022; 14(16):3274. https://doi.org/10.3390/nu14163274
Chicago/Turabian StyleYin, Linlin, Haihao Yan, Kangdi Chen, Zuhong Ji, Xiuhua Zhang, Guozhong Ji, and Bin Zhang. 2022. "Diet-Derived Circulating Antioxidants and Risk of Digestive System Tumors: A Mendelian Randomization Study" Nutrients 14, no. 16: 3274. https://doi.org/10.3390/nu14163274