One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy
Abstract
:1. Introduction
2. Participants and Methods
2.1. Participants
2.2. Study Protocol
2.3. Laboratory Measures
2.4. Appetite Measurements
2.5. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. One-Year Change in Weight, Appetite, Appetite Regulating Hormones, Caloric Intake, and Activity
3.3. Associations between Changes in Appetite Measures and Hormones and BMI Changes
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
SG | Sleeve Gastrectomy |
MBS | Metabolic Bariatric Surgery |
NS | Non-Surgical |
VAS | Visual Analog Scale |
BMI | Body Mass Index |
PYY | Peptide YY |
DSM-5 | Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition |
ELISA | Enzyme-Linked Immunosorbent Assay |
CV | Coefficient of Variation |
SEM | Standard Error Mean |
TCRC | Translational and Clinical Research Center |
AUC | Area Under Curve |
References
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Variable | Treatment | Baseline (SG n = 19, Controls n = 20) | One Year (SG n = 19, Controls n = 20) | One-Year Change | p-Value for within-Group Change | p-Value for between -Group Change |
---|---|---|---|---|---|---|
Weight (kg) | SG Controls | 138.9 ± 6.3 * 116.7 ± 4.4 * | 100.7 ± 6.9 115.7 ± 4.9 | −38.2 ± 3.4 −1.1 ± 1.9 | <0.0001 0.87 | <0.0001 |
BMI (kg/m2) | SG Controls | 48.2 ± 1.7 * 42.6 ± 1.0 * | 34.7 ± 2.1 41.7 ± 1.3 | −13.4 ± 1.1 −0.9 ± 0.7 | <0.0001 0.59 | <0.0001 |
DXA Measures of Body Composition, Total Caloric Intake, and Activity | ||||||
Fat Mass (kg) | SG Controls | 67.4 ± 3.2 * 56.3 ± 2.4 * | 40.7 ± 3.2 55.2 ± 2.7 | −26.7 ± 3.3 −1.1 ± 1.2 | <0.0001 0.40 | <0.0001 |
% Fat Mass | SG Controls | 49.6 ± 1.1 47.6 ± 0.9 | 40.0 ± 1.8 46.5 ± 1.0 | −9.6 ± 1.5 −1.1 ± 0.5 | <0.0001 0.99 | <0.0001 |
Lean Mass (kg) | SG Controls | 66.6 ± 2.5 60.0 ± 2.3 | 57.5 ± 2.2 61.1 ± 2.4 | −9.1 ± 1.4 1.0 ± 0.6 | <0.0001 0.99 | <0.0001 |
% Lean Mass | SG Controls | 49.2 ± 1.0 51.0 ± 0.9 | 58.3 ± 1.6 51.7 ± 1.0 | 9.1 ± 1.5 0.7 ± 0.6 | <0.0001 0.27 | <0.0001 |
Total Caloric Intake (Kcal) | SG Controls | 1586.4 ± 196.1 1568.6 ± 163.6 | 1194.3 ± 80.3 1591.0 ± 122.3 | −392.1 ± 179.4 22.3 ± 178.1 | 0.03 0.91 | 0.004a |
Activity (h/week) | SG Controls | 27.0 ± 5.3 28.3 ± 5.7 | 33.6 ± 4.6 27.2 ± 3.8 | 6.6 ± 6.5 −1.1 ± 6.8 | 0.35 0.76 | 0.95 a |
Average Sleep (h/week) | SG Controls | 50.9 ± 2.5 54.9 ± 1.6 | 48.3 ± 2.4 48.8 ± 2.1 | −2.6 ± 1.6 −6.1 ± 2.2 | 0.20 0.02 | 0.23 |
HORMONES | ||||||
Ghrelin (pg/mL) | SG Controls | 204.3 ± 35.0 167.8 ± 26.8 | 36.0 ± 8.3 247.0 ± 35.5 | −168.4 ± 33.4 79.2 ± 31.5 | <0.0001 0.13 | <0.0001 |
AUC Ghrelin (103 pg/mL) | SG Controls | 18.6 ± 2.2 17.3 ± 2.3 | 5.6 ± 1.3 16.7 ± 2.1 | −13.0 ± 1.6 −0.6 ± 1.4 | <0.0001 0.68 | <0.0001 |
PYY (pg/mL) | SG Controls | 91.2 ± 7.5 84.4 ± 7.4 | 83.2 ± 8.4 78.4 ± 7.8 | −8.1 ± 6.5 −6.1 ± 8.3 | 0.18 0.47 | 0.85 |
AUC PYY (103 pg/mL) | SG Controls | 13.3 ± 1.0 11.1 ± 0.7 | 17.6 ± 2.8 11.7 ± 1.1 | 4.3 ± 3.2 0.6 ± 1.0 | 0.21 0.55 | 0.49 |
Variable | Treatment | Baseline (SG n = 19, Controls n = 20) | One Year (SG n = 19, Controls n = 20) | One-Year Change | p-Value for within-Group 1-Year Change | p-Value for between-Group 1-Year Change |
HOMEOSTATIC APPETITE | ||||||
How hungry do you feel? | SG Controls | 61.9 ± 4.6 53.6 ± 5.5 | 55.3 ± 5.7 51.8 ± 4.8 | −6.6 ± 5.7 −1.8 ± 8.1 | 0.27 0.83 | 0.63 |
How much do you think you can eat? | SG Controls | 61.7 ± 3.6 60.7 ± 4.8 | 56.0 ± 3.6 62.5 ± 4.0 | −5.7 ± 4.6 1.8 ± 4.8 | 0.23 0.71 | 0.27 |
How full do you feel? | SG Controls | 18.6 ± 5.3 20.7 ± 5.5 | 23.8 ± 5.5 25.9 ± 4.7 | 5.2 ± 6.6 5.2 ± 7.6 | 0.63 0.26 | 0.66 a |
How satisfied do you feel? | SG Controls | 23.8 ± 4.7 25.7 ± 4.7 | 36.3 ± 4.6 36.5 ± 4.6 | 12.5 ± 6.1 10.9 ± 6.8 | 0.10 0.05 | 0.86 |
HEDONIC APPETITE | ||||||
How strong is your desire to eat your favorite food? | SG Controls | 40.4 ± 6.7 35.1 ± 5.6 | 42.7 ± 6.1 51.7 ± 5.6 | 2.3 ± 7.5 16.6 ± 7.3 | 0.57 0.03 | 0.13 a ± |
Would you like to eat something sweet? | SG Controls | 55.5 ± 6.7 62.1 ± 7.7 | 54.3 ± 7.6 57.2 ± 6.1 | −1.3 ± 6.8 −5.0 ± 11.2 | 1.00 0.59 | 0.08 a |
Would you like to eat something salty? | SG Controls | 44.9 ± 5.7 50.2 ± 5.6 | 35.0 ± 4.6 46.7 ± 5.8 | −10.0 ± 7.5 −3.5 ± 7.4 | 0.20 0.65 | 0.54 |
Would you like to eat something savory? | SG Controls | 38.5 ± 4.8 37.5 ± 5.3 | 35.5 ± 20.6 41.7 ± 20.1 | −2.9 ± 7.5 4.2 ± 7.1 | 0.70 0.56 | 0.49 |
Would you like to eat something fatty? | SG Controls | 65.1 ± 5.9 50.9 ± 6.9 | 55.8 ± 6.2 55.1 ± 5.8 | −9.2 ± 8.4 4.2 ± 9.7 | 0.29 0.67 | 0.31 |
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Singhal, V.; Nimmala, S.; Karzar, N.H.; Bredella, M.A.; Misra, M. One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy. Nutrients 2022, 14, 3054. https://doi.org/10.3390/nu14153054
Singhal V, Nimmala S, Karzar NH, Bredella MA, Misra M. One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy. Nutrients. 2022; 14(15):3054. https://doi.org/10.3390/nu14153054
Chicago/Turabian StyleSinghal, Vibha, Supritha Nimmala, Nazanin Hazhir Karzar, Miriam A. Bredella, and Madhusmita Misra. 2022. "One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy" Nutrients 14, no. 15: 3054. https://doi.org/10.3390/nu14153054
APA StyleSinghal, V., Nimmala, S., Karzar, N. H., Bredella, M. A., & Misra, M. (2022). One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy. Nutrients, 14(15), 3054. https://doi.org/10.3390/nu14153054