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Article

Efficacy of a Novel Therapeutic, Based on Natural Ingredients and Probiotics, in a Murine Model of Multiple Food Intolerance and Maldigestion

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 98166 Messina, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Franck Gael Carbonero
Nutrients 2022, 14(11), 2251; https://doi.org/10.3390/nu14112251
Received: 6 May 2022 / Revised: 24 May 2022 / Accepted: 26 May 2022 / Published: 27 May 2022
(This article belongs to the Section Prebiotics and Probiotics)
Patients with hypersensitive gut mucosa often suffer from food intolerances (FIs) associated with an inadequate gastrointestinal function that affects 15–20% of the population. Current treatments involve elimination diets, but require careful control, are difficult to maintain long-term, and diagnosis remains challenging. This study aims to evaluate the beneficial effects of a novel therapeutic of natural (NTN) origin containing food-grade polysaccharides, proteins, and grape seed extract to restore intestinal function in a murine model of fructose, carbohydrate, and fat intolerances. All experiments were conducted in four-week-old male CD1 mice. To induce FIs, mice were fed with either a high-carbohydrate diet (HCD), high-fat diet (HFD), or high-fructose diet (HFrD), respectively. After two weeks of treatment, several parameters and endpoints were evaluated such as food and water intake, body weight, histological score in several organs, gut permeability, intestinal epithelial integrity, and biochemical endpoints. Our results demonstrated that the therapeutic agent significantly restored gut barrier integrity and permeability compromised by every FIs induction. Restoration of intestinal function by NTN treatment has consequently improved tissue damage in several functional organs involved in the diagnostic of each intolerance such as the pancreas for HCD and liver for HFD and HFrD. Taken together, our results support NTN as a promising natural option in the non-pharmacological strategy for the recovery of intestinal dysregulation, supporting the well-being of the gastrointestinal tract. View Full-Text
Keywords: food intolerances (FIs); maldigestion; high-carbohydrate diet (HCD); high-fat diet (HFD); high-fructose diet (HFrD); polysaccharides; pea protein; grape seed extract; barrier integrity food intolerances (FIs); maldigestion; high-carbohydrate diet (HCD); high-fat diet (HFD); high-fructose diet (HFrD); polysaccharides; pea protein; grape seed extract; barrier integrity
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MDPI and ACS Style

Ardizzone, A.; Lanza, M.; Casili, G.; Campolo, M.; Paterniti, I.; Cuzzocrea, S.; Esposito, E. Efficacy of a Novel Therapeutic, Based on Natural Ingredients and Probiotics, in a Murine Model of Multiple Food Intolerance and Maldigestion. Nutrients 2022, 14, 2251. https://doi.org/10.3390/nu14112251

AMA Style

Ardizzone A, Lanza M, Casili G, Campolo M, Paterniti I, Cuzzocrea S, Esposito E. Efficacy of a Novel Therapeutic, Based on Natural Ingredients and Probiotics, in a Murine Model of Multiple Food Intolerance and Maldigestion. Nutrients. 2022; 14(11):2251. https://doi.org/10.3390/nu14112251

Chicago/Turabian Style

Ardizzone, Alessio, Marika Lanza, Giovanna Casili, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, and Emanuela Esposito. 2022. "Efficacy of a Novel Therapeutic, Based on Natural Ingredients and Probiotics, in a Murine Model of Multiple Food Intolerance and Maldigestion" Nutrients 14, no. 11: 2251. https://doi.org/10.3390/nu14112251

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