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Article

Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice

1
Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Korea
2
Department of Food Science and Technology, Institute of Food Science, Pukyong National University, Busan 48513, Korea
3
Division of Food Biotechnology, University of Science & Technology, Daejeon 34113, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Izquierdo-Pulido
Nutrients 2022, 14(11), 2249; https://doi.org/10.3390/nu14112249
Received: 1 April 2022 / Revised: 14 May 2022 / Accepted: 25 May 2022 / Published: 27 May 2022
(This article belongs to the Topic Applied Sciences in Functional Foods)
Sleep is one of the most essential factors required to maintain good health. However, the global prevalence of insomnia is increasing, and caffeine intake is a major trigger. The objective of this study was to investigate the inhibitory effect of black pepper, Piper nigrum extract (PE), on caffeine-induced sleep disruption and excitation in mice. Caffeine significantly decreased sleep duration in the pentobarbital-induced sleep test. It also resulted in a significant increase in sleep onset and a decrease in non-rapid eye movement sleep. Moreover, in an open-field test, caffeine-treated mice exhibited a significantly increased time in the center zone and total distance traveled. However, the co-administration of caffeine and PE did not result in similar arousal activities. Thus, our results suggest that PE can be used as a potential therapeutic agent to treat sleep problems and excitatory status associated with caffeine intake. View Full-Text
Keywords: black pepper; Piper nigrum; caffeine-induced sleepiness; sleep-promoting; hyperlocomotion black pepper; Piper nigrum; caffeine-induced sleepiness; sleep-promoting; hyperlocomotion
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MDPI and ACS Style

Yoon, M.; Jung, J.; Kim, M.; Lee, C.; Cho, S.; Um, M. Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice. Nutrients 2022, 14, 2249. https://doi.org/10.3390/nu14112249

AMA Style

Yoon M, Jung J, Kim M, Lee C, Cho S, Um M. Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice. Nutrients. 2022; 14(11):2249. https://doi.org/10.3390/nu14112249

Chicago/Turabian Style

Yoon, Minseok, Jonghoon Jung, Minjung Kim, Changho Lee, Suengmok Cho, and Minyoung Um. 2022. "Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice" Nutrients 14, no. 11: 2249. https://doi.org/10.3390/nu14112249

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