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Article

Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption

1
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain
2
Center of Brain, Behavior and Metabolism, Institute of Neurobiology, University of Lübeck, Marie Curie Street, 23562 Lübeck, Germany
3
Unitat de Nutrició i Salut, Centre Tecnològic de Catalunya, Eurecat, 43204 Reus, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Derek Renshaw and Mark Turner
Nutrients 2022, 14(11), 2246; https://doi.org/10.3390/nu14112246
Received: 26 April 2022 / Revised: 23 May 2022 / Accepted: 25 May 2022 / Published: 27 May 2022
(This article belongs to the Special Issue Diet, Adipose Tissue Dysfunction and Metabolic Disorders)
Consumption of grape seed proanthocyanidin extract (GSPE) has beneficial effects on the functionality of white adipose tissue (WAT). However, although WAT metabolism shows a clear diurnal rhythm, whether GSPE consumption could affect WAT rhythmicity in a time-dependent manner has not been studied. Ninety-six male Fischer rats were fed standard (STD, two groups) or cafeteria (CAF, four groups) diet for 9 weeks (n = 16 each group). From week 6 on, CAF diet animals were supplemented with vehicle or 25 mg GSPE/kg of body weight either at the beginning of the light/rest phase (ZT0) or at the beginning of the dark/active phase (ZT12). The two STD groups were also supplemented with vehicle at ZT0 or ZT12. In week 9, animals were sacrificed at 6 h intervals (n = 4) to analyze the diurnal rhythms of subcutaneous WAT metabolites by nuclear magnetic resonance spectrometry. A total of 45 metabolites were detected, 19 of which presented diurnal rhythms in the STD groups. Although most metabolites became arrhythmic under CAF diet, GSPE consumption at ZT12, but not at ZT0, restored the rhythmicity of 12 metabolites including compounds involved in alanine, aspartate, and glutamate metabolism. These results demonstrate that timed GSPE supplementation may restore, at least partially, the functional dynamics of WAT when it is consumed at the beginning of the active phase. This study opens an innovative strategy for time-dependent polyphenol treatment in obesity and metabolic diseases. View Full-Text
Keywords: acrophase; circacompare; chronobiology; chrononutrition; flavonoids; metabolomics; zeitgeber acrophase; circacompare; chronobiology; chrononutrition; flavonoids; metabolomics; zeitgeber
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MDPI and ACS Style

Colom-Pellicer, M.; Rodríguez, R.M.; Soliz-Rueda, J.R.; de Assis, L.V.M.; Navarro-Masip, È.; Quesada-Vázquez, S.; Escoté, X.; Oster, H.; Mulero, M.; Aragonès, G. Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption. Nutrients 2022, 14, 2246. https://doi.org/10.3390/nu14112246

AMA Style

Colom-Pellicer M, Rodríguez RM, Soliz-Rueda JR, de Assis LVM, Navarro-Masip È, Quesada-Vázquez S, Escoté X, Oster H, Mulero M, Aragonès G. Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption. Nutrients. 2022; 14(11):2246. https://doi.org/10.3390/nu14112246

Chicago/Turabian Style

Colom-Pellicer, Marina, Romina M. Rodríguez, Jorge R. Soliz-Rueda, Leonardo V.M. de Assis, Èlia Navarro-Masip, Sergio Quesada-Vázquez, Xavier Escoté, Henrik Oster, Miquel Mulero, and Gerard Aragonès. 2022. "Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption" Nutrients 14, no. 11: 2246. https://doi.org/10.3390/nu14112246

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