Bioenergetic Balance of Continuous Venovenous Hemofiltration, a Retrospective Analysis
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Bioenergetic Balance
3.2. Non-Intentional Calories
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
Amount of Subjects (ntotal) | 9 |
---|---|
Mean age | 70 ± 12 years |
Gender | |
| 6 |
| 3 |
Mean weight | 89 ± 28 kg |
Mean BMI | 30.3 ± 6.7 kg/m2 |
Mean APACHE II score | 30 ± 12 |
Ventilation (n) | |
| 4 |
| 5 |
30-day mortality (n/ntotal) | 7/9 |
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Prismocitrate ® 18/0 | Prismocal B22 ® | Biphozyl ® | NaCl 0.9% | |
---|---|---|---|---|
Na (mmol/L) | 140 | 140 | 140 | 154 |
K (mmol/L) | 0 | 4 | 4 | 0 |
Cl (mmol/L) | 86 | 120.5 | 122 | 154 |
Mg (mmol/L | 0 | 0 | 0.75 | 0 |
P (mmol/L) | 0 | 0 | 1–2 | 0 |
HCO3 (mmol/L) | 0 | 22 | 22 | 0 |
Citrate (mmol/L) | 18 | 0 | 0 | 0 |
Glucose (mmol/L) | 0 | 6.1 | 0 | 0 |
Lactate (mmol/L) | 0 | 3 | 0 | 0 |
Low Dose CVVH with Citrate | High Dose CVVH with Citrate | Low Dose CVVH without Citrate | |
---|---|---|---|
n = | 8 | 4 | 7 |
Blood flow (mL/min) | 150 ± 0 | 150 ± 0 | 150 ± 0 |
Predilution flow (mL/h) | 1756 ± 264 | 1700 ± 147 | 1721 ± 296 |
Postdilution flow | 506 ± 431 | 2300 ± 1036 | 464 ± 490 |
Postdilution fluid (n) | |||
| 1 | 0 | 1 |
| 3 | 2 | 3 |
| 4 | 2 | 3 |
Effluent flow (mL/h) | 2363 ± 476 | 4075 ± 974 | 2279 ± 551 |
Low Dose CVVH with Citrate | High Dose CVVH with Citrate | Low Dose CVVH without Citrate | ||
---|---|---|---|---|
Absolute bioenergetic balance (kcal/day) | Mean | 498 ± 110 | 262 ± 222 | −189 ± 77 |
Range | 339 to 681 | 56 to 565 | −298 to −92 | |
Relative bioenergetic balance (%) | Mean | 26 ± 9 | 17 ± 11 | −13 ± 8 |
Range | 14 to 42 | 7 to 32 | −28 to −5 |
Low Dose CVVH with Citrate | High Dose CVVH with Citrate | Low Dose CVVH without Citrate | p-Value | ||
---|---|---|---|---|---|
Gain due to dialysis fluid of non-intentional caloric containing molecules | Citrate (mmol/24 h) | 759 ± 114 | 734 ± 64 | 0 | <0.001 |
Glucose (g/24 h) | 6 ± 14 | 38 ± 45 | 7 ± 15 | 0.083 | |
Lactate (mmol/24 h) | 16 ± 38 | 104 ± 124 | 19 ± 40 | 0.083 | |
Loss in effluent of non-intentional caloric containing molecules | Citrate (mmol/24 h) | 168 ± 47 | 281 ± 73 | 0 | <0.001 |
Glucose (g/24 h) | 64 ± 28 | 107 ± 40 | 57 ± 22 | 0.032 | |
Lactate (mmol/24 h) | 64 ± 34 | 127 ± 74 | 60 ± 38 | 0.070 | |
Total balance of non-intentional caloric containing molecules | Citrate (mmol/24 h) | 591 ± 81 | 453 ± 60 | 0 | <0.001 |
Glucose (g/24 h) | −59 ± 24 | −69 ± 53 | −50 ± 20 | 0.607 | |
Lactate (mmol/24 h) | −48 ± 16 | −22 ± 84 | −42 ± 14 | 0.567 | |
Absolute caloric balance (kcal/day) | Citrate | 736 ± 101 | 564 ± 75 | 0 | <0.001 |
Glucose | −222 ± 90 | −262 ± 202 | −187 ± 74 | 0.584 | |
Lactate | −16 ± 5 | −7 ± 27 | 3 ± 15 | 0.032 | |
Relative caloric balance compared to the true Resting Energy Expenditure (REE) (%) | Citrate | 40 ± 14% (26 to 69%) | 44 ± 16% (34 to 69%) | 0% | <0.001 |
Glucose | −12 ± 7% (−25 to −5%) | −24 ± 24% (−57 to 0%) | −13 ± 8% (−28 to −5%) | 0.300 | |
Lactate | −1 ± 1% (−2 to 0%) | −1 ± 3% (−5 to 1%) | 0 ± 1% (−1 to 3%) | 0.200 |
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Jonckheer, J.; Van Hoorn, A.; Oshima, T.; De Waele, E. Bioenergetic Balance of Continuous Venovenous Hemofiltration, a Retrospective Analysis. Nutrients 2022, 14, 2112. https://doi.org/10.3390/nu14102112
Jonckheer J, Van Hoorn A, Oshima T, De Waele E. Bioenergetic Balance of Continuous Venovenous Hemofiltration, a Retrospective Analysis. Nutrients. 2022; 14(10):2112. https://doi.org/10.3390/nu14102112
Chicago/Turabian StyleJonckheer, Joop, Alex Van Hoorn, Taku Oshima, and Elisabeth De Waele. 2022. "Bioenergetic Balance of Continuous Venovenous Hemofiltration, a Retrospective Analysis" Nutrients 14, no. 10: 2112. https://doi.org/10.3390/nu14102112