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Curcumin May Prevent Basement Membrane Disassembly by Matrix Metalloproteinases and Progression of the Bladder Cancer

1
Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland
2
Department of Oncological Urology, The Franciszek Lukaszczyk Oncology Center, Romanowskiej 2, 85-796 Bydgoszcz, Poland
3
Department of Urology, Jan Biziel Memorial University Hospital, Ujejskiego 75, 85-168 Bydgoszcz, Poland
4
Department of Urology, District Hospital, 10 Lesna Street, 89-600 Chojnice, Poland
*
Author to whom correspondence should be addressed.
Current address: M. Curie 9, 85-090 Bydgoszcz, Poland.
These authors contributed equally to this work.
Academic Editor: Winston Craig
Nutrients 2022, 14(1), 32; https://doi.org/10.3390/nu14010032
Received: 8 October 2021 / Revised: 18 December 2021 / Accepted: 19 December 2021 / Published: 23 December 2021
(This article belongs to the Topic Novel Therapeutic Nutrient Molecules)
Authors present a review of crucial mechanisms contributing to the invasion of the basement membrane (BM) of the urothelium by cancer cells and to the progression of bladder cancer (BC). The breeching of the urothelial BM, facilitated by an aberrant activation of matrix metalloproteinases (MMP) is particularly perilous. Inhibition of activation of these proteinases constitutes a logic opportunity to restrain progression. Because of limited efficacy of current therapeutic methods, the search for the development of alternative approaches constitutes “the hot spot” of modern oncology. Recent studies revealed significant anticancer potential of natural phytochemicals. Especially, curcumin has emerged as a one of the most promising phytochemicals and showed its efficacy in several human malignancies. Therefore, this article addresses experimental and clinical data indicating multi-directional inhibitory effect of curcumin on the growth of bladder cancer. We particularly concentrate on the mechanisms, by which curcumin inhibits the MMP’s activities, thereby securing BM integrity and alleviating the eventual cancer invasion into the bladder muscles. Authors review the recently accumulating data, that curcumin constitutes a potent factor contributing to the more effective treatment of the bladder cancer. View Full-Text
Keywords: bladder cancer; basement membrane proteins; phytochemicals; curcumin; matrix metalloproteinases bladder cancer; basement membrane proteins; phytochemicals; curcumin; matrix metalloproteinases
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MDPI and ACS Style

Wroński, P.; Wroński, S.; Kurant, M.; Malinowski, B.; Wiciński, M. Curcumin May Prevent Basement Membrane Disassembly by Matrix Metalloproteinases and Progression of the Bladder Cancer. Nutrients 2022, 14, 32. https://doi.org/10.3390/nu14010032

AMA Style

Wroński P, Wroński S, Kurant M, Malinowski B, Wiciński M. Curcumin May Prevent Basement Membrane Disassembly by Matrix Metalloproteinases and Progression of the Bladder Cancer. Nutrients. 2022; 14(1):32. https://doi.org/10.3390/nu14010032

Chicago/Turabian Style

Wroński, Paweł, Stanisław Wroński, Marcin Kurant, Bartosz Malinowski, and Michał Wiciński. 2022. "Curcumin May Prevent Basement Membrane Disassembly by Matrix Metalloproteinases and Progression of the Bladder Cancer" Nutrients 14, no. 1: 32. https://doi.org/10.3390/nu14010032

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