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Article

Changes in Bone Metabolism and Antioxidant Defense Systems in Menopause-Induced Rats Fed Bran Extract from Dark Purple Rice (Oryza sativa L. Cv. Superjami)

1
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Korea
2
Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, Korea
3
Department of Agricultural Science, Korea National Open University, Seoul 03087, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: David J. Mela
Nutrients 2021, 13(9), 2926; https://doi.org/10.3390/nu13092926
Received: 20 July 2021 / Revised: 17 August 2021 / Accepted: 20 August 2021 / Published: 24 August 2021
(This article belongs to the Special Issue Low-Carbohydrate Diets and Health Outcomes)
Menopause is a matter of concern for women’s health due to a deficiency of female hormones; additionally, reactive oxygen species and aging can cause osteoporosis. Food becomes increasingly interesting as a menopausal woman’s alternative to hormone therapy. The effects of ethanol extracts from dark purple Superjami rice bran on bone metabolism and antioxidant defense systems in menopause-induced animal models were evaluated. Female rats underwent sham surgery or were ovariectomized to induce a menopause-like state. Rats were divided into a sham control group (SHAM), an ovariectomized control group (OVX), and an ovariectomized grou supplemented with Superjami rice bran extract group (OVX-S) and fed for 8 weeks. The OVX groups exhibited significantly more weight gain, amounts of bone turnover biochemical markers (alkaline phosphatase, osteocalcin, and C-terminal telopeptide), bone loss, lipid-peroxidation and oxidative stress than the SHAM group. However, Superjami bran extract added to the diet resulted in a significant reduction in body weight and lipid peroxidation, as well as enhanced bone metabolism and antioxidant enzyme activities, in ovariectomized rats. These results propound that extracts from Superjami rice bran have therapeutic potentiality against bone loss and oxidative stress in menopause-induced states and will be useful in preventing postmenopausal osteoporosis and oxidative damage. View Full-Text
Keywords: rice bran; Superjami; postmenopause; bone metabolism; oxidative stress; aging rice bran; Superjami; postmenopause; bone metabolism; oxidative stress; aging
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MDPI and ACS Style

Chung, S.I.; Ryu, S.N.; Kang, M.Y. Changes in Bone Metabolism and Antioxidant Defense Systems in Menopause-Induced Rats Fed Bran Extract from Dark Purple Rice (Oryza sativa L. Cv. Superjami). Nutrients 2021, 13, 2926. https://doi.org/10.3390/nu13092926

AMA Style

Chung SI, Ryu SN, Kang MY. Changes in Bone Metabolism and Antioxidant Defense Systems in Menopause-Induced Rats Fed Bran Extract from Dark Purple Rice (Oryza sativa L. Cv. Superjami). Nutrients. 2021; 13(9):2926. https://doi.org/10.3390/nu13092926

Chicago/Turabian Style

Chung, Soo I., Su N. Ryu, and Mi Y. Kang. 2021. "Changes in Bone Metabolism and Antioxidant Defense Systems in Menopause-Induced Rats Fed Bran Extract from Dark Purple Rice (Oryza sativa L. Cv. Superjami)" Nutrients 13, no. 9: 2926. https://doi.org/10.3390/nu13092926

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