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Plant Adaptogens—History and Future Perspectives

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria
Université Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, 63000 Clermont-Ferrand, France
Institut Universitaire de France (IUF), 1 rue Descartes, 75005 Paris, France
Author to whom correspondence should be addressed.
Academic Editor: Dariusz Nowak
Nutrients 2021, 13(8), 2861;
Received: 11 July 2021 / Revised: 12 August 2021 / Accepted: 17 August 2021 / Published: 20 August 2021
(This article belongs to the Section Phytochemicals and Human Health)
Adaptogens are synthetic compounds (bromantane, levamisole, aphobazole, bemethyl, etc.) or plant extracts that have the ability to enhance the body’s stability against physical loads without increasing oxygen consumption. Extracts from Panax ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, and Schisandra chinensis are considered to be naturally occurring adaptogens and, in particular, plant adaptogens. The aim of this study is to evaluate the use of plant adaptogens in the past and now, as well as to outline the prospects of their future applications. The use of natural adaptogens by humans has a rich history—they are used in recovery from illness, physical weakness, memory impairment, and other conditions. About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body’s resistance to stress and to improve physical endurance. Although now many people take plant adaptogens, the clinical trials on human are limited. The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection. In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes. View Full-Text
Keywords: plant adaptogens; Panax ginseng; Eleuterococcus senticosus; Rhaponticum carthamoides; Rhodiola rosea; Schisandra chinensis plant adaptogens; Panax ginseng; Eleuterococcus senticosus; Rhaponticum carthamoides; Rhodiola rosea; Schisandra chinensis
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MDPI and ACS Style

Todorova, V.; Ivanov, K.; Delattre, C.; Nalbantova, V.; Karcheva-Bahchevanska, D.; Ivanova, S. Plant Adaptogens—History and Future Perspectives. Nutrients 2021, 13, 2861.

AMA Style

Todorova V, Ivanov K, Delattre C, Nalbantova V, Karcheva-Bahchevanska D, Ivanova S. Plant Adaptogens—History and Future Perspectives. Nutrients. 2021; 13(8):2861.

Chicago/Turabian Style

Todorova, Velislava, Kalin Ivanov, Cédric Delattre, Vanya Nalbantova, Diana Karcheva-Bahchevanska, and Stanislava Ivanova. 2021. "Plant Adaptogens—History and Future Perspectives" Nutrients 13, no. 8: 2861.

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