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Systematic Review

The Effectiveness of Nutrition Interventions Combined with Exercise in Upper Gastrointestinal Cancers: A Systematic Review

1
Discipline of Physiotherapy, Trinity College Dublin, D08 W9RT Dublin, Ireland
2
John Stearne Medical Library, Trinity Centre for Health Sciences, D08 W9RT Dublin, Ireland
3
Trinity College Dublin, School of Medicine, D02 R590 Dublin, Ireland
4
School of Biological and Health Sciences, Technological University Dublin, Grangegorman, D07 XT95 Dublin, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Line Merethe Oldervoll
Nutrients 2021, 13(8), 2842; https://doi.org/10.3390/nu13082842
Received: 21 July 2021 / Revised: 13 August 2021 / Accepted: 14 August 2021 / Published: 18 August 2021
(This article belongs to the Special Issue Nutrition and Physical Exercise in the Patients with Cancer)
Malnutrition and muscle wasting are associated with impaired physical functioning and quality of life in oncology patients. Patients diagnosed with upper gastrointestinal (GI) cancers are considered at high risk of malnutrition and impaired function. Due to continuous improvement in upper GI cancer survival rates, there has been an increased focus on multimodal interventions aimed at minimizing the adverse effects of cancer treatments and enhancing survivors’ quality of life. The present study aimed to evaluate the effectiveness of combined nutritional and exercise interventions in improving muscle wasting, physical functioning, and quality of life in patients with upper GI cancer. A comprehensive search was conducted in MEDLINE, EMBASE, Web of Science, Cochrane Library, and CINHAL. Of the 4780 identified articles, 148 were selected for full-text review, of which 5 studies met the inclusion criteria. Whilst reviewed studies showed promising effects of multimodal interventions on physical functioning, no significant differences in postoperative complications and hospital stay were observed. Limited available evidence showed conflicting results regarding the effectiveness of these interventions on preserving muscle mass and improving health-related quality of life. Further studies examining the impact of nutrition and exercise interventions on upper GI patient outcomes are required and would benefit from reporting a core outcome set. View Full-Text
Keywords: cancer; gastrointestinal; nutrition; exercise; rehabilitation; multidisciplinary; body composition cancer; gastrointestinal; nutrition; exercise; rehabilitation; multidisciplinary; body composition
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MDPI and ACS Style

Sadeghi, F.; Mockler, D.; Guinan, E.M.; Hussey, J.; Doyle, S.L. The Effectiveness of Nutrition Interventions Combined with Exercise in Upper Gastrointestinal Cancers: A Systematic Review. Nutrients 2021, 13, 2842. https://doi.org/10.3390/nu13082842

AMA Style

Sadeghi F, Mockler D, Guinan EM, Hussey J, Doyle SL. The Effectiveness of Nutrition Interventions Combined with Exercise in Upper Gastrointestinal Cancers: A Systematic Review. Nutrients. 2021; 13(8):2842. https://doi.org/10.3390/nu13082842

Chicago/Turabian Style

Sadeghi, Fatemeh, David Mockler, Emer M. Guinan, Juliette Hussey, and Suzanne L. Doyle. 2021. "The Effectiveness of Nutrition Interventions Combined with Exercise in Upper Gastrointestinal Cancers: A Systematic Review" Nutrients 13, no. 8: 2842. https://doi.org/10.3390/nu13082842

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