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Article

Randomized Trial on the Effects of Dietary Potassium on Blood Pressure and Serum Potassium Levels in Adults with Chronic Kidney Disease

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School of Medicine, Johns Hopkins University, Baltimore, MD 21087, USA
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Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
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Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21087, USA
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The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD 21087, USA
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Herbert Wertheim School of Public Health and Human Longevity Science, University of California at San Diego, San Diego, CA 92093, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yoshiyuki Morishita
Nutrients 2021, 13(8), 2678; https://doi.org/10.3390/nu13082678
Received: 26 June 2021 / Revised: 21 July 2021 / Accepted: 29 July 2021 / Published: 31 July 2021
(This article belongs to the Special Issue The Role of Dietary Potassium in Human Health)
In the general population, an increased potassium (K) intake lowers blood pressure (BP). The effects of K have not been well-studied in individuals with chronic kidney disease (CKD). This randomized feeding trial with a 2-period crossover design compared the effects of diets containing 100 and 40 mmol K/day on BP in 29 adults with stage 3 CKD and treated or untreated systolic BP (SBP) 120–159 mmHg and diastolic BP (DBP) <100 mmHg. The primary outcome was 24 h ambulatory systolic BP. The higher-versus lower-K diet had no significant effect on 24 h SBP (−2.12 mm Hg; p = 0.16) and DBP (−0.70 mm Hg; p = 0.44). Corresponding differences in clinic BP were −4.21 mm Hg for SBP (p = 0.054) and −0.08 mm Hg for DBP (p = 0.94). On the higher-K diet, mean serum K increased by 0.21 mmol/L (p = 0.003) compared to the lower-K diet; two participants had confirmed hyperkalemia (serum K ≥ 5.5 mmol/L). In conclusion, a higher dietary intake of K did not lower 24 h SBP, while clinic SBP reduction was of borderline statistical significance. Additional trials are warranted to understand the health effects of increased K intake in individuals with CKD. View Full-Text
Keywords: potassium; blood pressure; hypertension; chronic kidney disease; hyperkalemia potassium; blood pressure; hypertension; chronic kidney disease; hyperkalemia
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MDPI and ACS Style

Turban, S.; Juraschek, S.P.; Miller, E.R., III; Anderson, C.A.M.; White, K.; Charleston, J.; Appel, L.J. Randomized Trial on the Effects of Dietary Potassium on Blood Pressure and Serum Potassium Levels in Adults with Chronic Kidney Disease. Nutrients 2021, 13, 2678. https://doi.org/10.3390/nu13082678

AMA Style

Turban S, Juraschek SP, Miller ER III, Anderson CAM, White K, Charleston J, Appel LJ. Randomized Trial on the Effects of Dietary Potassium on Blood Pressure and Serum Potassium Levels in Adults with Chronic Kidney Disease. Nutrients. 2021; 13(8):2678. https://doi.org/10.3390/nu13082678

Chicago/Turabian Style

Turban, Sharon, Stephen P. Juraschek, Edgar R. Miller III, Cheryl A.M. Anderson, Karen White, Jeanne Charleston, and Lawrence J. Appel 2021. "Randomized Trial on the Effects of Dietary Potassium on Blood Pressure and Serum Potassium Levels in Adults with Chronic Kidney Disease" Nutrients 13, no. 8: 2678. https://doi.org/10.3390/nu13082678

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