Next Article in Journal
Food Choice Decisions of Collegiate Division I Athletes: A Qualitative Exploratory Study
Next Article in Special Issue
Impact of School Closures, Precipitated by COVID-19, on Weight and Weight-Related Risk Factors among Schoolteachers: A Cross-Sectional Study
Previous Article in Journal
Evaluating Anticancer and Immunomodulatory Effects of Spirulina (Arthrospira) platensis and Gamma-Tocotrienol Supplementation in a Syngeneic Mouse Model of Breast Cancer
Previous Article in Special Issue
Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial
Article

Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19

1
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, 84505 Bratislava, Slovakia
2
Department of Psychiatry and Psychotherapy, Philipps-University Marburg, 35039 Marburg, Germany
3
Murck-Neuroscience, Westfield, NJ 07090, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: William B. Grant
Nutrients 2021, 13(7), 2321; https://doi.org/10.3390/nu13072321
Received: 19 May 2021 / Revised: 1 July 2021 / Accepted: 1 July 2021 / Published: 6 July 2021
Angiotensin converting enzyme 2 (ACE2) is a key entry point of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus known to induce Coronavirus disease 2019 (COVID-19). We have recently outlined a concept to reduce ACE2 expression by the administration of glycyrrhizin, a component of Glycyrrhiza glabra extract, via its inhibitory activity on 11beta hydroxysteroid dehydrogenase type 2 (11betaHSD2) and resulting activation of mineralocorticoid receptor (MR). We hypothesized that in organs such as the ileum, which co-express 11betaHSD2, MR and ACE2, the expression of ACE2 would be suppressed. We studied organ tissues from an experiment originally designed to address the effects of Glycyrrhiza glabra extract on stress response. Male Sprague Dawley rats were left undisturbed or exposed to chronic mild stress for five weeks. For the last two weeks, animals continued with a placebo diet or received a diet containing extract of Glycyrrhiza glabra root at a dose of 150 mg/kg of body weight/day. Quantitative PCR measurements showed a significant decrease in gene expression of ACE2 in the small intestine of rats fed with diet containing Glycyrrhiza glabra extract. This effect was independent of the stress condition and failed to be observed in non-target tissues, namely the heart and the brain cortex. In the small intestine we also confirmed the reduction of ACE2 at the protein level. Present findings provide evidence to support the hypothesis that Glycyrrhiza glabra extract may reduce an entry point of SARS-CoV-2. Whether this phenomenon, when confirmed in additional studies, is linked to the susceptibility of cells to the virus requires further studies. View Full-Text
Keywords: COVID-19; glycyrrhizin; mineralocorticoid receptor; toll like receptor 4; angiotensin converting enzyme; aldosterone COVID-19; glycyrrhizin; mineralocorticoid receptor; toll like receptor 4; angiotensin converting enzyme; aldosterone
Show Figures

Figure 1

MDPI and ACS Style

Jezova, D.; Karailiev, P.; Karailievova, L.; Puhova, A.; Murck, H. Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19. Nutrients 2021, 13, 2321. https://doi.org/10.3390/nu13072321

AMA Style

Jezova D, Karailiev P, Karailievova L, Puhova A, Murck H. Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19. Nutrients. 2021; 13(7):2321. https://doi.org/10.3390/nu13072321

Chicago/Turabian Style

Jezova, Daniela, Peter Karailiev, Lucia Karailievova, Agnesa Puhova, and Harald Murck. 2021. "Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19" Nutrients 13, no. 7: 2321. https://doi.org/10.3390/nu13072321

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop