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Review

Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment

1
Undergraduate Program, Harvard Extension School, Cambridge, MA 02138, USA
2
Department of Clinical Medicine, Pacific Northwest University of Health Sciences, Yakima, WA 98901, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Antonietta Panaro
Nutrients 2021, 13(7), 2206; https://doi.org/10.3390/nu13072206
Received: 4 June 2021 / Revised: 24 June 2021 / Accepted: 24 June 2021 / Published: 27 June 2021
Recent studies have highlighted the importance of vitamin K2 (VK2) in human health. However, there have been no clinical studies investigating the role of VK2 in the prevention or treatment of Alzheimer’s disease (AD), a debilitating disease for which currently there is no cure. In reviewing basic science research and clinical studies that have connected VK2 to factors involved in AD pathogenesis, we have found a growing body of evidence demonstrating that VK2 has the potential to slow the progression of AD and contribute to its prevention. In our review, we consider the antiapoptotic and antioxidant effects of VK2 and its impact on neuroinflammation, mitochondrial dysfunction, cognition, cardiovascular health, and comorbidities in AD. We also examine the link between dysbiosis and VK2 in the context of the microbiome’s role in AD pathogenesis. Our review is the first to consider the physiological roles of VK2 in the context of AD, and, given the recent shift in AD research toward nonpharmacological interventions, our findings emphasize the timeliness and need for clinical studies involving VK2. View Full-Text
Keywords: vitamin K2; menaquinone; Alzheimer’s disease; dementia; neurodegeneration; cognition; neuroinflammation; microglia; antioxidant; microbiome vitamin K2; menaquinone; Alzheimer’s disease; dementia; neurodegeneration; cognition; neuroinflammation; microglia; antioxidant; microbiome
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MDPI and ACS Style

Popescu, A.; German, M. Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment. Nutrients 2021, 13, 2206. https://doi.org/10.3390/nu13072206

AMA Style

Popescu A, German M. Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment. Nutrients. 2021; 13(7):2206. https://doi.org/10.3390/nu13072206

Chicago/Turabian Style

Popescu, Alexander, and Monica German. 2021. "Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment" Nutrients 13, no. 7: 2206. https://doi.org/10.3390/nu13072206

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