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Review

The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence

1
Neurology Outpatient Clinic, Department of Chronic Diseases, Hospital of Chronic Diseases Târgu Frumos, 705300 Iași, Romania
2
Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iași, Romania
3
Institute of Cardiovascular Diseases, 700503 Iasi, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Ryu Takechi, John Mamo and Virginie Lam
Nutrients 2021, 13(6), 2118; https://doi.org/10.3390/nu13062118
Received: 14 May 2021 / Revised: 13 June 2021 / Accepted: 18 June 2021 / Published: 20 June 2021
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
The burden of cognitive disorders is huge and still growing, however the etiology and the degree of cognitive impairment vary considerably. Neurodegenerative and vascular mechanisms were most frequently assessed in patients with dementia. Recent studies have shown the possible involvement of triglycerides levels in cognitive function through putative mechanisms such as brain blood barrier dysfunction or amyloid metabolism imbalance, but not all research in the field found this association. Several clinical studies evaluated the relationship between different forms of cognitive decline and levels of serum triglycerides, independent of other cardiovascular risk factors. This review focuses on the role of triglycerides in cognitive decline, cerebral amyloidosis and vascular impairment. Considering that the management of hypertriglyceridemia benefits from lifestyle modification, diet, and specific drug therapy, future studies are requested to appraise the triglycerides–cognitive impairment relationship. View Full-Text
Keywords: triglycerides; cognitive decline; dementia; Alzheimer’s triglycerides; cognitive decline; dementia; Alzheimer’s
MDPI and ACS Style

Dimache, A.M.; Șalaru, D.L.; Sascău, R.; Stătescu, C. The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence. Nutrients 2021, 13, 2118. https://doi.org/10.3390/nu13062118

AMA Style

Dimache AM, Șalaru DL, Sascău R, Stătescu C. The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence. Nutrients. 2021; 13(6):2118. https://doi.org/10.3390/nu13062118

Chicago/Turabian Style

Dimache, Alina M., Delia L. Șalaru, Radu Sascău, and Cristian Stătescu. 2021. "The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence" Nutrients 13, no. 6: 2118. https://doi.org/10.3390/nu13062118

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