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Volume 13
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10.3390/nu13062011
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Article

Dietary Patterns and Hepatocellular Carcinoma Risk among US Adults

by
Iman Moussa
1,
Rena S. Day
2,
Ruosha Li
3,
Xianglin L. Du
1,
Ahmed O. Kaseb
4,
Prasun K. Jalal
5,
Carrie Daniel-MacDougall
6,
Rikita I. Hatia
6,
Ahmed Abdelhakeem
4,
Asif Rashid
7,
Yun Shin Chun
8,
Donghui Li
4 and
Manal M. Hassan
6,*
1
Department of Epidemiology, Human Genetics and Environmental Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
2
Department of Epidemiology, Human Genetics and Environmental Sciences, Southwest Center for Occupational and Environmental Health, Michael & Susan Dell Center for Healthy Living, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
3
Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
4
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
5
Division of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
6
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
7
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
8
Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(6), 2011; https://doi.org/10.3390/nu13062011
Submission received: 6 May 2021 / Revised: 3 June 2021 / Accepted: 8 June 2021 / Published: 11 June 2021
(This article belongs to the Section Clinical Nutrition)
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Abstract

The objective of this study was to assess the association between dietary patterns and risk of hepatocellular carcinoma (HCC) among US adults in a hospital-based case-control study. We analyzed data from 641 cases and 1002 controls recruited at The University of Texas MD Anderson Cancer Center during 2001–2018. Cases were patients with a pathologically or radiologically confirmed new diagnosis of HCC; controls were cancer-free spouses of patients with cancers other than gastrointestinal, lung, liver, or head and neck cancer. Cases and controls were frequency-matched by age and sex. Dietary patterns were identified by principal component analysis. Odds ratios (ORs) and corresponding confidence intervals (CIs) were computed using unconditional logistic regression with adjustment for major HCC risk factors, including hepatitis B virus and hepatitis C virus infection. A vegetable-based dietary pattern was inversely associated with HCC risk (highest compared with lowest tertile: OR 0.66, 95% CI 0.46–0.94). A Western diet pattern was directly associated with HCC risk (highest compared with lowest tertile: OR 1.79, 95% CI 1.19–2.69). These findings emphasize the potential role of dietary intake in HCC prevention and clinical management.
Keywords: liver cancer; dietary patterns; case control liver cancer; dietary patterns; case control
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MDPI and ACS Style

Moussa, I.; Day, R.S.; Li, R.; Du, X.L.; Kaseb, A.O.; Jalal, P.K.; Daniel-MacDougall, C.; Hatia, R.I.; Abdelhakeem, A.; Rashid, A.; et al. Dietary Patterns and Hepatocellular Carcinoma Risk among US Adults. Nutrients 2021, 13, 2011. https://doi.org/10.3390/nu13062011

AMA Style

Moussa I, Day RS, Li R, Du XL, Kaseb AO, Jalal PK, Daniel-MacDougall C, Hatia RI, Abdelhakeem A, Rashid A, et al. Dietary Patterns and Hepatocellular Carcinoma Risk among US Adults. Nutrients. 2021; 13(6):2011. https://doi.org/10.3390/nu13062011

Chicago/Turabian Style

Moussa, Iman, Rena S. Day, Ruosha Li, Xianglin L. Du, Ahmed O. Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, and et al. 2021. "Dietary Patterns and Hepatocellular Carcinoma Risk among US Adults" Nutrients 13, no. 6: 2011. https://doi.org/10.3390/nu13062011

APA Style

Moussa, I., Day, R. S., Li, R., Du, X. L., Kaseb, A. O., Jalal, P. K., Daniel-MacDougall, C., Hatia, R. I., Abdelhakeem, A., Rashid, A., Chun, Y. S., Li, D., & Hassan, M. M. (2021). Dietary Patterns and Hepatocellular Carcinoma Risk among US Adults. Nutrients, 13(6), 2011. https://doi.org/10.3390/nu13062011

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