Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

Kravchenko, Lidia V.; Aksenov, Ilya V.; Nikitin, Nikolay S.; Guseva, Galina V.; Avrenyeva, Ludmila I.; Trusov, Nikita V.; Balakina, Anastasia S.; Tutelyan, Victor A.

doi:10.3390/nu13061999

Open AccessArticle

Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

by

Lidia V. Kravchenko

¹,

Ilya V. Aksenov

^1,*

,

Nikolay S. Nikitin

¹,

Galina V. Guseva

¹,

Ludmila I. Avrenyeva

¹,

Nikita V. Trusov

¹

,

Anastasia S. Balakina

¹ and

Victor A. Tutelyan

^1,2

¹

Federal Research Centre of Nutrition and Biotechnology, 2/14 Ustinsky Passage, 109240 Moscow, Russia

²

FSAEI HE I.M. Sechenov First MSMU MOH Russia (Sechenovskiy University), 8-2 Trubetskaya Street, 119991 Moscow, Russia

^*

Author to whom correspondence should be addressed.

Nutrients 2021, 13(6), 1999; https://doi.org/10.3390/nu13061999

Submission received: 13 May 2021 / Revised: 4 June 2021 / Accepted: 7 June 2021 / Published: 10 June 2021

(This article belongs to the Special Issue Diet, Liver, Oxidative Stress and Metabolic Syndrome)

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is currently estimated as the most prevalent chronic liver disease in all age groups. An increasing body of evidence obtained in experimental and clinical data indicates that oxidative stress is the most important pathogenic factor in the development of NAFLD. The study aimed to investigate the impact of α-lipoic acid (LA), widely used as an antioxidant, on the effects of a hypercaloric choline-deficient diet. Male Wistar rats were divided into three groups: control diet (C); hypercaloric choline-deficient diet (HCCD), and hypercaloric choline-deficient diet with α-lipoic acid (HCCD+LA). Supplementation of HCCD with LA for eight weeks led to a decrease in visceral adipose tissue/body weight ratio, the activity of liver glutathione peroxidase and paraoxonase-1, plasma, and liver total antioxidant activity, as well as an increase in liver/body weight ratio, liver total lipid and triglyceride content, and liver transaminase activities compared to the HCCD group without LA. In conclusion, our study shows that α-lipoic acid detains obesity development but exacerbates the severity of diet-induced oxidative stress and lipid accumulation in the liver of male Wistar rats fed a hypercaloric choline-deficient diet.

Keywords: non-alcoholic fatty liver disease; α-lipoic acid; hypercaloric choline-deficient diet; oxidative stress; liver lipid accumulation

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MDPI and ACS Style

Kravchenko, L.V.; Aksenov, I.V.; Nikitin, N.S.; Guseva, G.V.; Avrenyeva, L.I.; Trusov, N.V.; Balakina, A.S.; Tutelyan, V.A. Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet. Nutrients 2021, 13, 1999. https://doi.org/10.3390/nu13061999

AMA Style

Kravchenko LV, Aksenov IV, Nikitin NS, Guseva GV, Avrenyeva LI, Trusov NV, Balakina AS, Tutelyan VA. Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet. Nutrients. 2021; 13(6):1999. https://doi.org/10.3390/nu13061999

Chicago/Turabian Style

Kravchenko, Lidia V., Ilya V. Aksenov, Nikolay S. Nikitin, Galina V. Guseva, Ludmila I. Avrenyeva, Nikita V. Trusov, Anastasia S. Balakina, and Victor A. Tutelyan. 2021. "Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet" Nutrients 13, no. 6: 1999. https://doi.org/10.3390/nu13061999

APA Style

Kravchenko, L. V., Aksenov, I. V., Nikitin, N. S., Guseva, G. V., Avrenyeva, L. I., Trusov, N. V., Balakina, A. S., & Tutelyan, V. A. (2021). Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet. Nutrients, 13(6), 1999. https://doi.org/10.3390/nu13061999

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Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

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