Next Article in Journal
Relation of Serum Copper Status to Survival in COVID-19
Next Article in Special Issue
Inflammation and the Association of Vitamin D and Depressive Symptomatology
Previous Article in Journal
Amino Acid-Based Diet Prevents Lethal Infectious Diarrhea by Maintaining Body Water Balance in a Murine Citrobacter rodentium Infection Model
Previous Article in Special Issue
Dietary Intake of n-3 PUFA-Enriched Hen Eggs Changes Inflammatory Markers’ Concentration and Treg/Th17 Cells Distribution in Blood of Young Healthy Adults—A Randomised Study
Article

Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis

1
Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, 55131 Mainz, Germany
2
Center for Cardiology—Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany
3
German Center for Cardiovascular Research (DZHK)—Partner Site Rhine-Main, 55131 Mainz, Germany
4
Institute of Molecular Medicine, University Medical Center Mainz, 55131 Mainz, Germany
5
Focus Program Translational Neurosciences, University Medical Center Mainz, 55131 Mainz, Germany
6
Research Center for Immunotherapy, University Medical Center Mainz, 55131 Mainz, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: A. Catharine Ross
Nutrients 2021, 13(6), 1897; https://doi.org/10.3390/nu13061897
Received: 30 April 2021 / Revised: 24 May 2021 / Accepted: 28 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Effects of Nutrients on Immune and Inflammatory Responses)
Background: Psoriasis is a systemic inflammatory disorder, primarily characterized by skin plaques. It is linked to co-morbidities including cardiovascular disease and metabolic syndrome. Several studies demonstrate that dietary habits can influence psoriasis development and severity. However, the effect of different dietary protein levels on psoriasis development and severity is poorly understood. In this study, we examine the influence of dietary protein on psoriasis-like skin disease in mice. Methods: We fed male C57BL/6J mice with regular, low protein and high protein chow for 4 weeks. Afterwards, we induced psoriasis-like skin disease by topical imiquimod (IMQ)-treatment on ear and back skin. The local cutaneous and systemic inflammatory response was investigated using flow cytometry analysis, histology and quantitative rt-PCR. Results: After 5 days of IMQ-treatment, both diets reduced bodyweight in mice, whereas only the high protein diet slightly aggravated IMQ-induced skin inflammation. IMQ-treatment induced infiltration of myeloid cells, neutrophils, and monocytes/macrophages into skin and spleen independently of diet. After IMQ-treatment, circulating neutrophils and reactive oxygen species were increased in mice on low and high protein diets. Conclusion: Different dietary protein levels had no striking effect on IMQ-induced psoriasis but aggravated the systemic pro-inflammatory phenotype. View Full-Text
Keywords: protein diet; psoriasis; inflammation; psoriasis-like skin disease; imiquimod protein diet; psoriasis; inflammation; psoriasis-like skin disease; imiquimod
Show Figures

Figure 1

MDPI and ACS Style

Knopp, T.; Bieler, T.; Jung, R.; Ringen, J.; Molitor, M.; Jurda, A.; Münzel, T.; Waisman, A.; Wenzel, P.; Karbach, S.H.; Wild, J. Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis. Nutrients 2021, 13, 1897. https://doi.org/10.3390/nu13061897

AMA Style

Knopp T, Bieler T, Jung R, Ringen J, Molitor M, Jurda A, Münzel T, Waisman A, Wenzel P, Karbach SH, Wild J. Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis. Nutrients. 2021; 13(6):1897. https://doi.org/10.3390/nu13061897

Chicago/Turabian Style

Knopp, Tanja, Tabea Bieler, Rebecca Jung, Julia Ringen, Michael Molitor, Annika Jurda, Thomas Münzel, Ari Waisman, Philip Wenzel, Susanne H. Karbach, and Johannes Wild. 2021. "Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis" Nutrients 13, no. 6: 1897. https://doi.org/10.3390/nu13061897

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop