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Article

Amino Acid-Based Diet Prevents Lethal Infectious Diarrhea by Maintaining Body Water Balance in a Murine Citrobacter rodentium Infection Model

1
Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan
2
Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan
3
Co-Creation Center, Meiji Holdings Co., Ltd., Tokyo 192-0919, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Evasio Pasini, Francesco S. Dioguardi and Giovanni Corsetti
Nutrients 2021, 13(6), 1896; https://doi.org/10.3390/nu13061896
Received: 12 May 2021 / Revised: 23 May 2021 / Accepted: 27 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Amino Acid Nutrition and Metabolism Related to Health and Well Being)
Infectious diarrhea is one of the most important health problems worldwide. Although nutritional status influences the clinical manifestation of various enteric pathogen infections, the effect of diet on enteric infectious diseases remains unclear. Using a fatal infectious diarrheal model, we found that an amino acid-based diet (AD) protected susceptible mice infected with the enteric pathogen Citrobacter rodentium. While the mice fed other diets, including a regular diet, were highly susceptible to C. rodentium infection, AD-fed mice had an increased survival rate. An AD did not suppress C. rodentium colonization or intestinal damage; instead, it prevented diarrhea-induced dehydration by increasing water intake. An AD altered the plasma and fecal amino acid levels and changed the gut microbiota composition. Treatment with glutamate, whose level was increased in the plasma and feces of AD-fed mice, promoted water intake and improved the survival of C. rodentium-infected mice. Thus, an AD changes the systemic amino acid balance and protects against lethal infectious diarrhea by maintaining total body water content. View Full-Text
Keywords: amino acid-based diet; Citrobacter rodentium; dehydration; diarrhea; enteric infection amino acid-based diet; Citrobacter rodentium; dehydration; diarrhea; enteric infection
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MDPI and ACS Style

Kimizuka, T.; Seki, N.; Yamaguchi, G.; Akiyama, M.; Higashi, S.; Hase, K.; Kim, Y.-G. Amino Acid-Based Diet Prevents Lethal Infectious Diarrhea by Maintaining Body Water Balance in a Murine Citrobacter rodentium Infection Model. Nutrients 2021, 13, 1896. https://doi.org/10.3390/nu13061896

AMA Style

Kimizuka T, Seki N, Yamaguchi G, Akiyama M, Higashi S, Hase K, Kim Y-G. Amino Acid-Based Diet Prevents Lethal Infectious Diarrhea by Maintaining Body Water Balance in a Murine Citrobacter rodentium Infection Model. Nutrients. 2021; 13(6):1896. https://doi.org/10.3390/nu13061896

Chicago/Turabian Style

Kimizuka, Tatsuki, Natsumi Seki, Genki Yamaguchi, Masahiro Akiyama, Seiichiro Higashi, Koji Hase, and Yun-Gi Kim. 2021. "Amino Acid-Based Diet Prevents Lethal Infectious Diarrhea by Maintaining Body Water Balance in a Murine Citrobacter rodentium Infection Model" Nutrients 13, no. 6: 1896. https://doi.org/10.3390/nu13061896

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