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Lutein Has a Positive Impact on Brain Health in Healthy Older Adults: A Systematic Review of Randomized Controlled Trials and Cohort Studies

by 1,2,†, 1,2,*,†, 3 and 2,4
1
Department of Cognitive Health Science, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai 980-8575, Japan
2
Smart Aging Research Center, Tohoku University, Seiryo-machi 4-1, Sendai 980-8575, Japan
3
Faculty of Science and Engineering, Anglia Ruskin University, Cambridge CB1 1PT, UK
4
Department of Functional Brain Imaging, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai 980-8575, Japan
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Academic Editor: Paolo Brambilla
Nutrients 2021, 13(6), 1746; https://doi.org/10.3390/nu13061746
Received: 5 April 2021 / Revised: 7 May 2021 / Accepted: 18 May 2021 / Published: 21 May 2021
(This article belongs to the Special Issue Dietary Intake and Aging Brain)
A previous systematic review revealed that lutein intake leads to improved cognitive function among older adults. However, the association between lutein intake and brain health remains unclear. Methods: We searched the Web of Science, PubMed, PsycInfo, and Cochrane Library for research papers. The criteria were (1) an intervention study using oral lutein intake or a cross-sectional study that examined lutein levels and the brain, (2) participants were older adults, and (3) brain activities or structures were measured using a brain imaging technique (magnetic resonance imaging (MRI) or electroencephalography (EEG)). Results: Seven studies using MRI (brain activities during rest, cognitive tasks, and brain structure) and two studies using EEG were included. We mainly focused on MRI studies. Three intervention studies using MRI indicated that 10 mg lutein intake over 12 months had a positive impact on healthy older adults’ brain activities during learning, resting-state connectivity, and gray matter volumes. Four cross-sectional studies using MRI suggested that lutein was positively associated with brain structure and neural efficiency during cognitive tasks. Conclusion: Although only nine studies that used similar datasets were reviewed, this systematic review indicates that lutein has beneficial effects on healthy older adults’ brain health. View Full-Text
Keywords: lutein; carotenoid; brain; MRI; VBM; systematic review lutein; carotenoid; brain; MRI; VBM; systematic review
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MDPI and ACS Style

Yagi, A.; Nouchi, R.; Butler, L.; Kawashima, R. Lutein Has a Positive Impact on Brain Health in Healthy Older Adults: A Systematic Review of Randomized Controlled Trials and Cohort Studies. Nutrients 2021, 13, 1746. https://doi.org/10.3390/nu13061746

AMA Style

Yagi A, Nouchi R, Butler L, Kawashima R. Lutein Has a Positive Impact on Brain Health in Healthy Older Adults: A Systematic Review of Randomized Controlled Trials and Cohort Studies. Nutrients. 2021; 13(6):1746. https://doi.org/10.3390/nu13061746

Chicago/Turabian Style

Yagi, Ayano, Rui Nouchi, Laurie Butler, and Ryuta Kawashima. 2021. "Lutein Has a Positive Impact on Brain Health in Healthy Older Adults: A Systematic Review of Randomized Controlled Trials and Cohort Studies" Nutrients 13, no. 6: 1746. https://doi.org/10.3390/nu13061746

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