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Article

Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis

1
Department of Anatomy, Division of Human Biology, School of Medicine, International Medical University, Kuala Lumpur 57000, Malaysia
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Division of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, International Medical University, Kuala Lumpur 57000, Malaysia
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Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor 47500, Malaysia
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Department of Medicine, Lincoln University College, Kelana Jaya, Selangor 47301, Malaysia
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College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Elisabetta Benedetti
Nutrients 2021, 13(5), 1583; https://doi.org/10.3390/nu13051583
Received: 7 March 2021 / Revised: 4 April 2021 / Accepted: 7 April 2021 / Published: 10 May 2021
(This article belongs to the Special Issue Nutrition and Parkinson's Disease)
Parkinson’s disease (PD) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (SN) in the midbrain due to loss of dopaminergic neurons. Emerging studies revealed the promising effects of some nutrient compounds in reducing the risk of PD. One such nutrient compound that possess neuroprotective effects and prevents neurodegeneration is tocotrienol (T3), a vitamin E family member. In the present study, a single dose intracisternal injection of 250 µg 6-hydroxydopamine (6-OHDA) was used to induce parkinsonism in male Sprague Dawley (SD) rats. Forty-eight hours post injection, the SD rats were orally supplemented with alpha (α)- and gamma (γ)-T3 for 28 days. The neuroprotective effects of α- and γ-T3 were evaluated using behavioural studies and immunohistochemistry (IHC). The findings from this study revealed that supplementation of α- and γ-T3 was able to ameliorate the motor deficits induced by 6-OHDA and improve the neuronal functions by reducing inflammation, reversing the neuronal degradation, and preventing further reduction of dopaminergic neurons in the SN and striatum (STR) fibre density. View Full-Text
Keywords: vitamin E; tocotrienols; tyrosine hydroxylase; Parkinson’s disease; neurofunctions; neuroglia; neurofilaments; glial fibrillary acidic protein vitamin E; tocotrienols; tyrosine hydroxylase; Parkinson’s disease; neurofunctions; neuroglia; neurofilaments; glial fibrillary acidic protein
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MDPI and ACS Style

Kumari, M.; Ramdas, P.; Radhakrishnan, A.K.; Kutty, M.K.; Haleagrahara, N. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients 2021, 13, 1583. https://doi.org/10.3390/nu13051583

AMA Style

Kumari M, Ramdas P, Radhakrishnan AK, Kutty MK, Haleagrahara N. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. 2021; 13(5):1583. https://doi.org/10.3390/nu13051583

Chicago/Turabian Style

Kumari, Mangala, Premdass Ramdas, Ammu K. Radhakrishnan, Methil K. Kutty, and Nagaraja Haleagrahara. 2021. "Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis" Nutrients 13, no. 5: 1583. https://doi.org/10.3390/nu13051583

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