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Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity

Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA 92521, USA
Academic Editors: Armin Alaedini, Christine Feinle-Bisset and Michael Horowitz
Nutrients 2021, 13(4), 1214; https://doi.org/10.3390/nu13041214
Received: 1 March 2021 / Revised: 1 April 2021 / Accepted: 2 April 2021 / Published: 7 April 2021
(This article belongs to the Special Issue Appetite and Satiety Control-Gut Mechanisms)
Gut-brain signaling controls food intake and energy homeostasis, and its activity is thought to be dysregulated in obesity. We will explore new studies that suggest the endocannabinoid (eCB) system in the upper gastrointestinal tract plays an important role in controlling gut-brain neurotransmission carried by the vagus nerve and the intake of palatable food and other reinforcers. A focus will be on studies that reveal both indirect and direct interactions between eCB signaling and vagal afferent neurons. These investigations identify (i) an indirect mechanism that controls nutrient-induced release of peptides from the gut epithelium that directly interact with corresponding receptors on vagal afferent neurons, and (ii) a direct mechanism via interactions between eCBs and cannabinoid receptors expressed on vagal afferent neurons. Moreover, the impact of diet-induced obesity on these pathways will be considered. View Full-Text
Keywords: endocannabinoid; CB1 receptor; gut-brain; intestine; food intake; reward endocannabinoid; CB1 receptor; gut-brain; intestine; food intake; reward
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MDPI and ACS Style

DiPatrizio, N.V. Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity. Nutrients 2021, 13, 1214. https://doi.org/10.3390/nu13041214

AMA Style

DiPatrizio NV. Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity. Nutrients. 2021; 13(4):1214. https://doi.org/10.3390/nu13041214

Chicago/Turabian Style

DiPatrizio, Nicholas V. 2021. "Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity" Nutrients 13, no. 4: 1214. https://doi.org/10.3390/nu13041214

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