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Article

Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study

1
MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK
2
Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK
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NIHR Cambridge Biomedical Research Centre—Diet, Anthropometry and Physical Activity Group, MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK
4
Department of Paediatric Medicine, University of Cambridge, Cambridge CB2 0QQ, UK
5
Cambridge Universities NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Louise Brough
Nutrients 2021, 13(4), 1156; https://doi.org/10.3390/nu13041156
Received: 30 January 2021 / Revised: 23 March 2021 / Accepted: 29 March 2021 / Published: 31 March 2021
Childhood obesity is an area of intense concern internationally and is influenced by events during antenatal and postnatal life. Although pregnancy complications, such as gestational diabetes and large-for-gestational-age birthweight have been associated with increased obesity risk in offspring, very few successful interventions in pregnancy have been identified. We describe a study protocol to identify if a reduced calorie diet in pregnancy can reduce adiposity in children to 3 years of age. The dietary intervention in gestational diabetes (DiGest) study is a randomised, controlled trial of a reduced calorie diet provided by a whole-diet replacement in pregnant women with gestational diabetes. Women receive a weekly dietbox intervention from enrolment until delivery and are blinded to calorie allocation. This follow-up study will assess associations between a reduced calorie diet in pregnancy with offspring adiposity and maternal weight and glycaemia. Anthropometry will be performed in infants and mothers at 3 months, 1, 2 and 3 years post-birth. Glycaemia will be assessed using bloodspot C-peptide in infants and continuous glucose monitoring with HbA1c in mothers. Data regarding maternal glycaemia in pregnancy, maternal nutrition, infant birthweight, offspring feeding behaviour and milk composition will also be collected. The DiGest follow-up study is expected to take 5 years, with recruitment finishing in 2026. View Full-Text
Keywords: gestational diabetes mellitus; pregnancy; study protocol; randomised controlled trial; large for gestational age; complex intervention; calorie restriction; maternal weight gain; childhood obesity; adiposity; type 2 diabetes; prevention gestational diabetes mellitus; pregnancy; study protocol; randomised controlled trial; large for gestational age; complex intervention; calorie restriction; maternal weight gain; childhood obesity; adiposity; type 2 diabetes; prevention
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MDPI and ACS Style

Jones, D.; De Lucia Rolfe, E.; Rennie, K.L.; Griep, L.M.O.; Kusinski, L.C.; Hughes, D.J.; Brage, S.; Ong, K.K.; Beardsall, K.; Meek, C.L. Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study. Nutrients 2021, 13, 1156. https://doi.org/10.3390/nu13041156

AMA Style

Jones D, De Lucia Rolfe E, Rennie KL, Griep LMO, Kusinski LC, Hughes DJ, Brage S, Ong KK, Beardsall K, Meek CL. Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study. Nutrients. 2021; 13(4):1156. https://doi.org/10.3390/nu13041156

Chicago/Turabian Style

Jones, Danielle, Emanuella De Lucia Rolfe, Kirsten L. Rennie, Linda M. Oude Griep, Laura C. Kusinski, Deborah J. Hughes, Soren Brage, Ken K. Ong, Kathryn Beardsall, and Claire L. Meek. 2021. "Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study" Nutrients 13, no. 4: 1156. https://doi.org/10.3390/nu13041156

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