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Article

Time-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults

1
Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA
2
Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE 19713, USA
3
Salk Institute for Biological Studies, La Jolla, CA 92037, USA
4
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
5
Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA
6
Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Roberto Iacone
Nutrients 2021, 13(4), 1155; https://doi.org/10.3390/nu13041155
Received: 10 March 2021 / Revised: 26 March 2021 / Accepted: 27 March 2021 / Published: 31 March 2021
(This article belongs to the Special Issue Diet and Bone Health)
Weight loss is a major focus of research and public health efforts. Time-restricted eating (TRE) is shown to be effective for weight loss, but the impact on bone is unclear. Short-term TRE studies show no effect on bone mineral density (BMD), but no study has measured bone turnover markers. This secondary analysis examined the effect of 12 weeks of TRE vs. unrestricted eating on bone turnover and BMD. Overweight and obese adults aged 18–65 y (n = 20) were randomized to TRE (ad libitum 8-h eating window) or non-TRE. Serum N-terminal propeptide of type I collagen (P1NP), cross-linked N-telopeptide of type I collagen (NTX), and parathyroid hormone (PTH) levels were measured and dual-energy X-ray absorptiometry (DXA) scans were taken pre- and post-intervention. In both groups, P1NP decreased significantly (p = 0.04) but trended to a greater decrease in the non-TRE group (p = 0.07). The treatment time interaction for bone mineral content (BMC) was significant (p = 0.02), such that BMC increased in the TRE group and decreased in the non-TRE group. Change in P1NP was inversely correlated with change in weight (p = 0.04) overall, but not within each group. These findings suggest that TRE does not adversely affect bone over a moderate timeframe. Further research should examine the long-term effects of TRE on bone. View Full-Text
Keywords: time-restricted eating; bone turnover markers; bone health; humans time-restricted eating; bone turnover markers; bone health; humans
MDPI and ACS Style

Lobene, A.J.; Panda, S.; Mashek, D.G.; Manoogian, E.N.C.; Hill Gallant, K.M.; Chow, L.S. Time-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults. Nutrients 2021, 13, 1155. https://doi.org/10.3390/nu13041155

AMA Style

Lobene AJ, Panda S, Mashek DG, Manoogian ENC, Hill Gallant KM, Chow LS. Time-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults. Nutrients. 2021; 13(4):1155. https://doi.org/10.3390/nu13041155

Chicago/Turabian Style

Lobene, Andrea J., Satchidananda Panda, Douglas G. Mashek, Emily N. C. Manoogian, Kathleen M. Hill Gallant, and Lisa S. Chow. 2021. "Time-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults" Nutrients 13, no. 4: 1155. https://doi.org/10.3390/nu13041155

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