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Article

Acceptability and Feasibility of a 13-Week Pilot Randomised Controlled Trial Testing the Effects of Incremental Doses of Beetroot Juice in Overweight and Obese Older Adults

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Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK
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Faculty of Applied Medical Sciences, Clinical Nutrition Department, Umm Al-Qura University, Makkah 21421, Saudi Arabia
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Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK
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Department of Geriatrics, St Bortolo Hospital, Vicenza, 37030 Verona, Italy
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Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK
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Nutrition Trials at Northumbria (NUTRAN), Northumbria University, Newcastle Upon Tyne NE1 8ST, UK
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School of Human Movement and Nutrition Sciences, University of Queensland, St. Lucia, QLD 4067, Australia
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Endocrinology and Nutrition Department, Divino Espirito Santo Hospital, D. Manuel I Avenue, 9500-370 Azores, Portugal
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School of Life Sciences, Queen’s Medical Centre, The University of Nottingham Medical School, Nottingham NG7 2UH, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Antoni Sureda
Nutrients 2021, 13(3), 769; https://doi.org/10.3390/nu13030769
Received: 24 January 2021 / Revised: 18 February 2021 / Accepted: 22 February 2021 / Published: 26 February 2021
Nitrate-rich food can increase nitric oxide production and improve vascular and brain functions. This study examines the feasibility of a randomised controlled trial (RCT) testing the effects of prolonged consumption of different doses of dietary nitrate (NO3) in the form of beetroot juice (BJ) in overweight and obese older participants. A single-blind, four-arm parallel pilot RCT was conducted in 62 overweight and obese (30.4 ± 4 kg/m2) older participants (mean ± standard deviation (SD), 66 ± 4 years). Participants were randomized to: (1) high-NO3 (HN: 2 × 70 mL BJ/day) (2) medium-NO3 (MN: 70 mL BJ/day), (3) low-NO3 (LN: 70 mL BJ on alternate days) or (4) Placebo (PL: 70 mL of NO3-depleted BJ on alternate days), for 13 weeks. Compliance was checked by a daily log of consumed BJ, NO3 intake, and by measuring NO3 and NO2 concentrations in plasma, saliva, and urine samples. Fifty participants completed the study. Self-reported compliance to the interventions was >90%. There were significant positive linear relationships between NO3 dose and the increase in plasma and urinary NO3 concentration (R2 = 0.71, p < 0.001 and R2 = 0.46 p < 0.001, respectively), but relationships between NO3 dose and changes in salivary NO3 and NO2 were non-linear (R2 = 0.35, p = 0.002 and R2 = 0.23, p = 0.007, respectively). The results confirm the feasibility of prolonged BJ supplementation in older overweight and obese adults. View Full-Text
Keywords: dietary nitrate; older adults; overweight/obese dietary nitrate; older adults; overweight/obese
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MDPI and ACS Style

Babateen, A.M.; Shannon, O.M.; O’Brien, G.M.; Okello, E.; Khan, A.A.; Rubele, S.; Wightman, E.; Smith, E.; McMahon, N.; Olgacer, D.; Koehl, C.; Fostier, W.; Mendes, I.; Kennedy, D.; Mathers, J.C.; Siervo, M. Acceptability and Feasibility of a 13-Week Pilot Randomised Controlled Trial Testing the Effects of Incremental Doses of Beetroot Juice in Overweight and Obese Older Adults. Nutrients 2021, 13, 769. https://doi.org/10.3390/nu13030769

AMA Style

Babateen AM, Shannon OM, O’Brien GM, Okello E, Khan AA, Rubele S, Wightman E, Smith E, McMahon N, Olgacer D, Koehl C, Fostier W, Mendes I, Kennedy D, Mathers JC, Siervo M. Acceptability and Feasibility of a 13-Week Pilot Randomised Controlled Trial Testing the Effects of Incremental Doses of Beetroot Juice in Overweight and Obese Older Adults. Nutrients. 2021; 13(3):769. https://doi.org/10.3390/nu13030769

Chicago/Turabian Style

Babateen, Abrar M., Oliver M. Shannon, Gerard M. O’Brien, Edward Okello, Anmar A. Khan, Sofia Rubele, Emma Wightman, Ellen Smith, Nicholas McMahon, Dilara Olgacer, Christina Koehl, William Fostier, Inês Mendes, David Kennedy, John C. Mathers, and Mario Siervo. 2021. "Acceptability and Feasibility of a 13-Week Pilot Randomised Controlled Trial Testing the Effects of Incremental Doses of Beetroot Juice in Overweight and Obese Older Adults" Nutrients 13, no. 3: 769. https://doi.org/10.3390/nu13030769

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