Next Article in Journal
Food Patterns among Chinese Immigrants Living in the South of Spain
Previous Article in Journal
The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals

Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era

Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, Spain
Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo, 36310 Vigo, Spain
Department of Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, 60131 Ancona, Italy
Department of Periodontology, Dental School, University of Sevilla, 41004 Sevilla, Spain
AgroScience & Food Research Group, Universidad de Las Américas, Quito 170125, Ecuador
King Fahd Medical Research Center, King Abdulaziz University, Jedda 21589, Saudi Arabia
Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: M. Luisa Bonet
Nutrients 2021, 13(3), 763;
Received: 7 January 2021 / Revised: 16 February 2021 / Accepted: 24 February 2021 / Published: 26 February 2021
Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed. View Full-Text
Keywords: rheumatoid arthritis; diet; nutrigenomics; proteomics; metabolomics; microbiome; microbiomics rheumatoid arthritis; diet; nutrigenomics; proteomics; metabolomics; microbiome; microbiomics
Show Figures

Graphical abstract

MDPI and ACS Style

Cassotta, M.; Forbes-Hernandez, T.Y.; Cianciosi, D.; Elexpuru Zabaleta, M.; Sumalla Cano, S.; Dominguez, I.; Bullon, B.; Regolo, L.; Alvarez-Suarez, J.M.; Giampieri, F.; Battino, M. Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era. Nutrients 2021, 13, 763.

AMA Style

Cassotta M, Forbes-Hernandez TY, Cianciosi D, Elexpuru Zabaleta M, Sumalla Cano S, Dominguez I, Bullon B, Regolo L, Alvarez-Suarez JM, Giampieri F, Battino M. Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era. Nutrients. 2021; 13(3):763.

Chicago/Turabian Style

Cassotta, Manuela, Tamara Y. Forbes-Hernandez, Danila Cianciosi, Maria Elexpuru Zabaleta, Sandra Sumalla Cano, Irma Dominguez, Beatriz Bullon, Lucia Regolo, Josè M. Alvarez-Suarez, Francesca Giampieri, and Maurizio Battino. 2021. "Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era" Nutrients 13, no. 3: 763.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop