Next Article in Journal
Prospective Association of the Portfolio Diet with All-Cause and Cause-Specific Mortality Risk in the Mr. OS and Ms. OS Study
Previous Article in Journal
Awareness of Fluid Losses Does Not Impact Thirst during Exercise in the Heat: A Double-Blind, Cross-Over Study
Review

Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance

Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark
*
Authors to whom correspondence should be addressed.
Academic Editor: Antonio Brunetti 
Nutrients 2021, 13(12), 4358; https://doi.org/10.3390/nu13124358
Received: 28 September 2021 / Revised: 24 November 2021 / Accepted: 25 November 2021 / Published: 3 December 2021
(This article belongs to the Section Micronutrients and Human Health)
The study was conducted to comprehensively assess the association of the concentration of vitamin D in the blood and insulin resistance in non-diabetic subjects. The objective was to pool the results from all observational studies from the beginning of 1980 to August 2021. PubMed, Medline and Embase were systematically searched for the observational studies. Filters were used for more focused results. A total of 2248 articles were found after raw search which were narrowed down to 32 articles by the systematic selection of related articles. Homeostatic Model Assessment of Insulin Resistance (HOMAIR) was used as the measure of insulin resistance and correlation coefficient was used as a measure of the relationship between vitamin D levels and the insulin resistance. Risk of bias tables and summary plots were built using Revman software version 5.3 while Comprehensive meta-analysis version 3 was used for the construction of forest plot. The results showed an inverse association between the status of vitamin D and insulin resistance (r = −0.217; 95% CI = −0.161 to −0.272; p = 0.000). A supplement of vitamin D can help reduce the risk of insulin resistance; however further studies, like randomized controlled trials are needed to confirm the results. View Full-Text
Keywords: Homeostatic Model Assessment of Insulin Resistance; HOMA-IR; vitamin D deficiency; type 2 diabetes (T2D); body mass index; BMI; insulin resistance Homeostatic Model Assessment of Insulin Resistance; HOMA-IR; vitamin D deficiency; type 2 diabetes (T2D); body mass index; BMI; insulin resistance
Show Figures

Figure 1

MDPI and ACS Style

Rafiq, S.; Jeppesen, P.B. Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance. Nutrients 2021, 13, 4358. https://doi.org/10.3390/nu13124358

AMA Style

Rafiq S, Jeppesen PB. Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance. Nutrients. 2021; 13(12):4358. https://doi.org/10.3390/nu13124358

Chicago/Turabian Style

Rafiq, Shamaila, and Per B. Jeppesen. 2021. "Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance" Nutrients 13, no. 12: 4358. https://doi.org/10.3390/nu13124358

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop