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Article

Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation

1
Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minumaku, Saitama 337-8570, Japan
2
Department of Bio-Science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minumaku, Saitama 337-8570, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Toshihiko Yada and Lindsay Brown
Nutrients 2021, 13(12), 4214; https://doi.org/10.3390/nu13124214
Received: 15 September 2021 / Revised: 19 November 2021 / Accepted: 22 November 2021 / Published: 24 November 2021
We previously found increases in uncoupling protein (Ucp)-1 transcription in brown adipose tissue (BAT) of mice following a single oral dose of flavan 3-ol (FL)s, a fraction of catechins and procyanidins. It was confirmed that these changes were totally reduced by co-treatment of adrenaline blockers. According to these previous results, FLs possibly activate sympathetic nervous system (SNS). In this study, we confirmed the marked increase in urinary catecholamine (CA) s projecting SNS activity following a single dose of 50 mg/kg FLs. In addition, we examined the impact of the repeated administration of 50 mg/kg FLs for 14 days on adipose tissues in mice. In BAT, FLs tended to increase the level of Ucp-1 along with significant increase of thermogenic transcriptome factors expressions, such as peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and PR domain-containing (PRDM)1. Expression of browning markers, CD137 and transmembrane protein (TMEM) 26, in addition to PGC-1α were increased in epididymal adipose (eWAT) by FLs. A multilocular morphology with cell size reduction was shown in the inguinal adipose (iWAT), together with increasing the level of Ucp-1 by FLs. These results exert that FLs induce browning in adipose, and this change is possibly produced by the activation of the SNS. View Full-Text
Keywords: flavan-3-ols; adipose; browning; catecholamine; sympathetic nerve flavan-3-ols; adipose; browning; catecholamine; sympathetic nerve
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MDPI and ACS Style

Ishii, Y.; Muta, O.; Teshima, T.; Hirasima, N.; Odaka, M.; Fushimi, T.; Fujii, Y.; Osakabe, N. Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation. Nutrients 2021, 13, 4214. https://doi.org/10.3390/nu13124214

AMA Style

Ishii Y, Muta O, Teshima T, Hirasima N, Odaka M, Fushimi T, Fujii Y, Osakabe N. Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation. Nutrients. 2021; 13(12):4214. https://doi.org/10.3390/nu13124214

Chicago/Turabian Style

Ishii, Yuko, Orie Muta, Tomohiro Teshima, Nayuta Hirasima, Minayu Odaka, Taiki Fushimi, Yasuyuki Fujii, and Naomi Osakabe. 2021. "Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation" Nutrients 13, no. 12: 4214. https://doi.org/10.3390/nu13124214

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