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Article

Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota

1
Multimodal Laboratory Medicine Research Area, Unit of Human Microbiome, Bambino Gesù Children’s Hospital, IRCCS, 00147 Rome, Italy
2
Dipartimento di Medicina e Chirurgia Traslazionale, Fondazione Policlinico Universitario A. Gemelli IRCCS—Università Cattolica del Sacro Cuore, 00168 Rome, Italy
3
CEMAD—IBD UNIT—Unità Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, 00168 Rome, Italy
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Unit of Microbiology and Diagnostic Immunology, Unit of Microbiomics and Multimodal Laboratory Medicine Research Area, Unit of Human Microbiome, Department of Diagnostic and Laboratory Medicine, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
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Saint Camillus International University of Health Sciences-UniCamillus, 00131 Rome, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Current address: Alleanza Contro il Cancro, 00161 Rome, Italy.
§
Current address: Dipartimento di Medicina Molecolare, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza Università di Roma, 00161 Rome, Italy.
Academic Editor: Lutz Schomburg
Nutrients 2021, 13(12), 4188; https://doi.org/10.3390/nu13124188
Received: 1 November 2021 / Revised: 10 November 2021 / Accepted: 16 November 2021 / Published: 23 November 2021
(This article belongs to the Section Micronutrients and Human Health)
Nutritional deficiencies are common in inflammatory bowel diseases (IBD). In patients, magnesium (Mg) deficiency is associated with disease severity, while in murine models, dietary Mg supplementation contributes to restoring mucosal function. Since Mg availability modulates key bacterial functions, including growth and virulence, we investigated whether the beneficial effects of Mg supplementation during colitis might be mediated by gut microbiota. The effects of dietary Mg modulation were assessed in a murine model of dextran sodium sulfate (DSS)-induced colitis by monitoring magnesemia, weight, and fecal consistency. Gut microbiota were analyzed by 16S-rRNA based profiling on fecal samples. Mg supplementation improved microbiota richness in colitic mice, increased abundance of Bifidobacterium and reduced Enterobacteriaceae. KEEG pathway analysis predicted an increase in biosynthetic metabolism, DNA repair and translation pathways during Mg supplementation and in the presence of colitis, while low Mg conditions favored catabolic processes. Thus, dietary Mg supplementation increases bacteria involved in intestinal health and metabolic homeostasis, and reduces bacteria involved in inflammation and associated with human diseases, such as IBD. These findings suggest that Mg supplementation may be a safe and cost-effective strategy to ameliorate disease symptoms and restore a beneficial intestinal flora in IBD patients. View Full-Text
Keywords: Bifidobacterium; dextran sodium sulfate; inflammatory bowel disease; dysbiosis; Enterobacteriacee; magnesemia; magnesium supplementation; metabolism Bifidobacterium; dextran sodium sulfate; inflammatory bowel disease; dysbiosis; Enterobacteriacee; magnesemia; magnesium supplementation; metabolism
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MDPI and ACS Style

Del Chierico, F.; Trapani, V.; Petito, V.; Reddel, S.; Pietropaolo, G.; Graziani, C.; Masi, L.; Gasbarrini, A.; Putignani, L.; Scaldaferri, F.; Wolf, F.I. Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota. Nutrients 2021, 13, 4188. https://doi.org/10.3390/nu13124188

AMA Style

Del Chierico F, Trapani V, Petito V, Reddel S, Pietropaolo G, Graziani C, Masi L, Gasbarrini A, Putignani L, Scaldaferri F, Wolf FI. Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota. Nutrients. 2021; 13(12):4188. https://doi.org/10.3390/nu13124188

Chicago/Turabian Style

Del Chierico, Federica, Valentina Trapani, Valentina Petito, Sofia Reddel, Giuseppe Pietropaolo, Cristina Graziani, Letizia Masi, Antonio Gasbarrini, Lorenza Putignani, Franco Scaldaferri, and Federica I. Wolf. 2021. "Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota" Nutrients 13, no. 12: 4188. https://doi.org/10.3390/nu13124188

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